標題: | Reverse thermo-responsive hydrogels prepared from Pluronic F127 and gelatin composite materials |
作者: | Yeh, Mei-Yu Zhao, Jiong-Yao Hsieh, Yi-Ru Lin, Jhong-Hua Chen, Fang-Yi Chakravarthy, Rajan Deepan Chung, Pei-Chun Lin, Hsin-Chieh Hung, Shih-Chieh 材料科學與工程學系 Department of Materials Science and Engineering |
公開日期: | 1-一月-2017 |
摘要: | Gelatin is an important hydrocolloid which has widespread applications in the pharmaceutical industry and biomedical science. However, despite its significance, clinical applications of gelatin are largely limited because of its gel-to-solution transition around human body temperature. In this work, we developed a series of F127-gelatin composite hydrogels with reverse thermo-responsive properties. The stiffness of F127-gelatin hydrogels can be adjusted by varying the types and contents of gelatin (type A, GA and type B, GB). The results of rheological data showed that F127-GA gels have higher gel strengths than those of F127-GB, which might be due to different isoelectric points between GA and GB. In addition, F127-gelatin gels showed significant cell viability and biocompatibility for human mesenchymal stem cells, indicating that these discovered hydrogels can serve as potential biomaterials and implantable scaffolds for applications in tissue engineering and regenerative medicine. |
URI: | http://dx.doi.org/10.1039/c7ra01118k http://hdl.handle.net/11536/145403 |
ISSN: | 2046-2069 |
DOI: | 10.1039/c7ra01118k |
期刊: | RSC ADVANCES |
Volume: | 7 |
Issue: | 34 |
起始頁: | 21252 |
結束頁: | 21257 |
顯示於類別: | 期刊論文 |