標題: | Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis |
作者: | Yan, Yung-Jhe Huang, Ting-Wei Cheng, Nai-Lun Hsieh, Yao-Fang Tsai, Ming-Hsui Chiou, Jin-Chern Duann, Jeng-Ren Lin, Yung-Jiun Yang, Chin-Siang Mang Ou-Yang 分子醫學與生物工程研究所 電機工程學系 電控工程研究所 Institute of Molecular Medicine and Bioengineering Department of Electrical and Computer Engineering Institute of Electrical and Control Engineering |
關鍵字: | autofluorescence;oral cancer;multispectrum;LED;medical and biological imaging;optical diagnosis;tissue diagnostics statics for medicine |
公開日期: | 1-四月-2017 |
摘要: | Oral cancer is a serious and growing problem in many developing and developed countries. To improve the cancer screening procedure, we developed a portable light-emitting-diode (LED)-induced autofluorescence (LIAF) imager that contains two wavelength LED excitation light sources and multiple filters to capture ex vivo oral tissue autofluorescence images. Compared with conventional means of oral cancer diagnosis, the LIAF imager is a handier, faster, and more highly reliable solution. The compact design with a tiny probe allows clinicians to easily observe autofluorescence images of hidden areas located in concave deep oral cavities. The ex vivo trials conducted in Taiwan present the design and prototype of the portable LIAF imager used for analyzing 31 patients with 221 measurement points. Using the normalized factor of normal tissues under the excitation source with 365 nm of the central wavelength and without the bandpass filter, the results revealed that the sensitivity was larger than 84%, the specificity was not smaller than over 76%, the accuracy was about 80%, and the area under curve of the receiver operating characteristic (ROC) was achieved at about 87%, respectively. The fact shows the LIAF spectroscopy has the possibilities of ex vivo diagnosis and noninvasive examinations for oral cancer. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) |
URI: | http://dx.doi.org/10.1117/1.JBO.22.4.045007 http://hdl.handle.net/11536/145479 |
ISSN: | 1083-3668 |
DOI: | 10.1117/1.JBO.22.4.045007 |
期刊: | JOURNAL OF BIOMEDICAL OPTICS |
Volume: | 22 |
Issue: | 4 |
起始頁: | 0 |
結束頁: | 0 |
顯示於類別: | 期刊論文 |