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dc.contributor.authorLin, Yu-Weien_US
dc.contributor.authorRaj, Emmanuel Naveenen_US
dc.contributor.authorLiao, Wei-Siangen_US
dc.contributor.authorLin, Johnsonen_US
dc.contributor.authorLiu, Kuang-Kaien_US
dc.contributor.authorChen, Ting-Huaen_US
dc.contributor.authorCheng, Hsiao-Chunen_US
dc.contributor.authorWang, Chi-Chingen_US
dc.contributor.authorLi, Lily Yien_US
dc.contributor.authorChen, Chinpiaoen_US
dc.contributor.authorChao, Jui-Ien_US
dc.date.accessioned2019-04-03T06:43:57Z-
dc.date.available2019-04-03T06:43:57Z-
dc.date.issued2017-08-29en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://dx.doi.org/10.1038/s41598-017-09983-8en_US
dc.identifier.urihttp://hdl.handle.net/11536/145981-
dc.description.abstractThe poor intracellular uptake and non-specific binding of anticancer drugs into cancer cells are the bottlenecks in cancer therapy. Nanocarrier platforms provide the opportunities to improve the drug efficacy. Here we show a carbon-based nanomaterial nanodiamond (ND) that carried paclitaxel (PTX), a microtubule inhibitor, and cetuximab (Cet), a specific monoclonal antibody against epidermal growth factor receptor (EGFR), inducing mitotic catastrophe and tumor inhibition in human colorectal cancer (CRC). ND-PTX blocked the mitotic progression, chromosomal separation, and induced apoptosis in the CRC cells; however, NDs did not induce these effects. Conjugation of ND-PTX with Cet (ND-PTX-Cet) was specifically binding to the EGFR-positive CRC cells and enhanced the mitotic catastrophe and apoptosis induction. Besides, ND-PTX-Cet markedly decreased tumor size in the xenograft EGFR-expressed human CRC tumors of nude mice. Moreover, ND-PTX-Cet induced the mitotic marker protein phospho-histone 3 (Ser10) and apoptotic protein active-caspase 3 for mitotic catastrophe and apoptosis. Taken together, this study demonstrated that the co-delivery of PTX and Cet by ND enhanced the effects of mitotic catastrophe and apoptosis in vitro and in vivo, which may be applied in the human CRC therapy.en_US
dc.language.isoen_USen_US
dc.titleCo-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibitionen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-017-09983-8en_US
dc.identifier.journalSCIENTIFIC REPORTSen_US
dc.citation.volume7en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000408538100056en_US
dc.citation.woscount5en_US
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