Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, Yu-Wei | en_US |
dc.contributor.author | Raj, Emmanuel Naveen | en_US |
dc.contributor.author | Liao, Wei-Siang | en_US |
dc.contributor.author | Lin, Johnson | en_US |
dc.contributor.author | Liu, Kuang-Kai | en_US |
dc.contributor.author | Chen, Ting-Hua | en_US |
dc.contributor.author | Cheng, Hsiao-Chun | en_US |
dc.contributor.author | Wang, Chi-Ching | en_US |
dc.contributor.author | Li, Lily Yi | en_US |
dc.contributor.author | Chen, Chinpiao | en_US |
dc.contributor.author | Chao, Jui-I | en_US |
dc.date.accessioned | 2019-04-03T06:43:57Z | - |
dc.date.available | 2019-04-03T06:43:57Z | - |
dc.date.issued | 2017-08-29 | en_US |
dc.identifier.issn | 2045-2322 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1038/s41598-017-09983-8 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/145981 | - |
dc.description.abstract | The poor intracellular uptake and non-specific binding of anticancer drugs into cancer cells are the bottlenecks in cancer therapy. Nanocarrier platforms provide the opportunities to improve the drug efficacy. Here we show a carbon-based nanomaterial nanodiamond (ND) that carried paclitaxel (PTX), a microtubule inhibitor, and cetuximab (Cet), a specific monoclonal antibody against epidermal growth factor receptor (EGFR), inducing mitotic catastrophe and tumor inhibition in human colorectal cancer (CRC). ND-PTX blocked the mitotic progression, chromosomal separation, and induced apoptosis in the CRC cells; however, NDs did not induce these effects. Conjugation of ND-PTX with Cet (ND-PTX-Cet) was specifically binding to the EGFR-positive CRC cells and enhanced the mitotic catastrophe and apoptosis induction. Besides, ND-PTX-Cet markedly decreased tumor size in the xenograft EGFR-expressed human CRC tumors of nude mice. Moreover, ND-PTX-Cet induced the mitotic marker protein phospho-histone 3 (Ser10) and apoptotic protein active-caspase 3 for mitotic catastrophe and apoptosis. Taken together, this study demonstrated that the co-delivery of PTX and Cet by ND enhanced the effects of mitotic catastrophe and apoptosis in vitro and in vivo, which may be applied in the human CRC therapy. | en_US |
dc.language.iso | en_US | en_US |
dc.title | Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41598-017-09983-8 | en_US |
dc.identifier.journal | SCIENTIFIC REPORTS | en_US |
dc.citation.volume | 7 | en_US |
dc.citation.spage | 0 | en_US |
dc.citation.epage | 0 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | 分子醫學與生物工程研究所 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.contributor.department | Institute of Molecular Medicine and Bioengineering | en_US |
dc.identifier.wosnumber | WOS:000408538100056 | en_US |
dc.citation.woscount | 5 | en_US |
Appears in Collections: | Articles |
Files in This Item:
If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.