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dc.contributor.authorChen, Min-Lingen_US
dc.contributor.authorLin, Bor-Shyhen_US
dc.contributor.authorSu, Cheng-Weien_US
dc.contributor.authorLin, Yen-Binen_US
dc.contributor.authorChen, Mei-Yenen_US
dc.contributor.authorShen, Jen-Hsiangen_US
dc.contributor.authorChang, Chang-Chengen_US
dc.date.accessioned2018-08-21T05:54:29Z-
dc.date.available2018-08-21T05:54:29Z-
dc.date.issued2017-09-01en_US
dc.identifier.issn0196-8092en_US
dc.identifier.urihttp://dx.doi.org/10.1002/lsm.22667en_US
dc.identifier.urihttp://hdl.handle.net/11536/146020-
dc.description.abstractBackground and Objectives: The majority of patients with diabetes foot ulcer have peripheral arterial disease. The technique of near infrared spectroscopy (NIRS) used to monitor the dorsal foot blood circulation condition is by measuring the absorption differences between oxyhemoglobin and deoxy-hemoglobin. Study Designs/Materials and Methods: Patients with diabetic foot ulcer (DFU) treated in our wound care center were divided into two sub-groups based on the Duplex ultrasound or angiography. Patients with peripheral arterial disease (PAD) and non-peripheral arterial disease were divided into group A1 and A2, respectively. We applied wireless NIRS on patients' dorsal foot to assess the peripheral circulation by continuously detect the signal penetrating the tissue while patients were asked to do Buerger's exercise. The same procedure was also repeated on 15 healthy participants as control group B. Results: From January to August 2015, 30 patients with DFU (Group A) were enrolled in the study, 9 patients in Group A1 and 21 patients in Group A2. Tissue concentration of oxygenated hemoglobin (HbO2) in each group varied in a similar trend among five stages of Buerger's exercise. HbO2 concentration increases at post-exercise stages in all groups (P = 0.006 in Group A1, P = 0.223 in Group A2, P = 0.03 in Group B), however, there were significant difference in both pre-and postexercise stages (P = 0.001 and P = 0.01, respectively) between Group A and B. Moreover, significant differences (P = 0.0009) of HbO2 were also found between Group A1 and A2 in pre-exercise status, but no significant difference (P = 0.294) was found in postexercise status. Similar results were also found in total hemoglobin (Hb) concentration analyses. Conclusions: Buerger's exercise could increase peripheral HbO2 and totalHb circulation in patients with diabetes foot ulcer. The NIRS could continuously and quantitatively monitor real-time peripheral circulation inpostural changes and is novel to rehabilitation program. A larger scale study to prove the accuracy of NIRS system in detecting peripheral circulation could be worthwhile.(C) 2017 Wiley Periodicals, Inc.en_US
dc.language.isoen_USen_US
dc.subjectnear infrared spectroscopyen_US
dc.subjectdiabetes foot ulceren_US
dc.subjectBuerger's exerciseen_US
dc.titleThe Application of Wireless Near Infrared Spectroscopy on Detecting Peripheral Circulation in Patients With Diabetes Foot Ulcer When Doing Buerger's Exerciseen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/lsm.22667en_US
dc.identifier.journalLASERS IN SURGERY AND MEDICINEen_US
dc.citation.volume49en_US
dc.citation.spage652en_US
dc.citation.epage657en_US
dc.contributor.department影像與生醫光電研究所zh_TW
dc.contributor.departmentInstitute of Imaging and Biomedical Photonicsen_US
dc.identifier.wosnumberWOS:000409263500003en_US
Appears in Collections:Articles