標題: trans-Stilbene C-Glycosides: Synthesis by a Microwave-Assisted Heck Reaction and Evaluation of the SGLT-2 Inhibitory Activity
作者: Ponnapalli, Kalyana Kumar
Adak, Avijit Kumar
Das, Anindya
Song, Jen-Shin
Wu, Szu-Huei
Sun, Chung-Ming
Lin, Chun-Cheng
應用化學系
Department of Applied Chemistry
關鍵字: cross-coupling;glycosylation;inhibitors;microwave chemistry;palladium
公開日期: 1-Sep-2017
摘要: A protocol for the microwave-assisted Heck coupling reaction of C-aryl glycosides and styrenes has been developed for the synthesis of mono-and bis(C-glycoside) stilbenes. This method exclusively provides C-glycoside trans-stilbenes in good yields. The Pd-catalyzed Heck coupling re-action was successfully applied to various functionalized C-glycosyl aryl iodides and various substituted styrenes to deliver several C-glycoside trans-stilbenes with high selectivity. The obtained C-glycosyl trans-stilbenes were also examined for human SGLT-2 inhibitory activity.
URI: http://dx.doi.org/10.1002/ajoc.201700148
http://hdl.handle.net/11536/146075
ISSN: 2193-5807
DOI: 10.1002/ajoc.201700148
期刊: ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume: 6
起始頁: 1308
結束頁: 1321
Appears in Collections:Articles