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dc.contributor.authorLiu, Ming-Kaien_US
dc.contributor.authorHuang, Keng-Shiangen_US
dc.contributor.authorChang, Jia-Yawen_US
dc.contributor.authorWu, Chun-Hanen_US
dc.contributor.authorLin, Yu-Chengen_US
dc.date.accessioned2019-04-03T06:47:03Z-
dc.date.available2019-04-03T06:47:03Z-
dc.date.issued2007-01-01en_US
dc.identifier.isbn978-0-8194-6578-8en_US
dc.identifier.issn0277-786Xen_US
dc.identifier.urihttp://dx.doi.org/10.1117/12.705413en_US
dc.identifier.urihttp://hdl.handle.net/11536/146411-
dc.description.abstractIn this paper the manipulation of monodisperse Ca-alginate microparticles using a polymer'-based CD-like microfluidic platform and a reaction of external gelation is presented. Our strategy was based on associating the rapid injection molding process for cross-junction microchannel with the sheath focusing effect to form uniform water-in-oil (w/o) emulsions. These fine emulsions, consisting of 1.5% w/v Na-alginate, were then dripped into an oil solution containing 20% w/v calcium chloride (CaCl2) to accomplish Ca-alginate microspheres in an efficient manner. We have demonstrated that one can control the size of Ca-alginate microparticles from 20 mu m to 50 mu m in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. Experimental data showed that for a given fixed dispersed phase flow (sample flow), the emulsion size decreased as the average velocity of the continuous phase (oil flow) increased. The proposed CD-like microfluidic platform is capable of generating relatively uniform micro-droplets and has the advantages of active control of droplet diameter, simple and low cost process, and high throughput.en_US
dc.language.isoen_USen_US
dc.subjectinjection moldingen_US
dc.subjectalginateen_US
dc.subjectmicrofluidicen_US
dc.subjectemulsionen_US
dc.titleUsing a CD-like microfluidic platform for uniform calcium alginate drug carrier generationen_US
dc.typeProceedings Paperen_US
dc.identifier.doi10.1117/12.705413en_US
dc.identifier.journalMICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS Ven_US
dc.citation.volume6465en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department機械工程學系zh_TW
dc.contributor.departmentDepartment of Mechanical Engineeringen_US
dc.identifier.wosnumberWOS:000245834700007en_US
dc.citation.woscount1en_US
Appears in Collections:Conferences Paper


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