Title: Multi-Objective Sample Preparation Algorithm for Microfluidic Biochips Supporting Various Mixing Models
Authors: Lei, Yung-Chun
Lin, Tung-Hsuan
Huang, Juinn-Dar
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
Keywords: Lab-on-a-chip (LoC);microfluidic biochips;sample preparation;various mixing models;multi-objective optimization
Issue Date: 1-Jan-2016
Abstract: Sample preparation is one of the most crucial processes in most biochemical applications. Reagents are repeatedly diluted in an appropriate sequence to get a target solution with a specific concentration value. For flow-based microfluidic biochips (FMFBs), several research works have been proposed for reactant minimization. In this paper, we propose the first sample preparation algorithm for microfluidic biochips with various mixing models that can perform multi-objective optimization simultaneously. It first formulates the problem in a network-flow model and then solves it through integer linear programming (ILP). Experimental results show that the proposed method can provide better solutions (in terms of reactant, waste, and operation jointly) as compared with the prior art.
URI: http://hdl.handle.net/11536/146657
Journal: 2016 29TH IEEE INTERNATIONAL SYSTEM-ON-CHIP CONFERENCE (SOCC)
Begin Page: 96
End Page: 101
Appears in Collections:Conferences Paper