標題: | Carotid atherosclerosis and cognitive function in midlife: The beaver dam offspring study |
作者: | Zhong, Wenjun Cruickshanks, Karen J. Huang, Guan-Hua Klein, Barbara E. K. Klein, Ronald Nieto, F. Javier Pankow, James S. Schubert, Carla R. 交大名義發表 National Chiao Tung University |
關鍵字: | Atherosclerosis;Cognitive function;Epidemiology |
公開日期: | 1-十一月-2011 |
摘要: | Background: Atherosclerosis may be associated with cognitive function; however the studies are few, especially among midlife adults. Methods: Participants in the beaver dam offspring study who had cognitive test data and gradable carotid artery ultrasound scans were included (n = 2794, mean age: 49 years). Atherosclerosis was measured by carotid intima-media thickness (IMT) and the presence of plaque. Cognitive function was measured by the trail making test (TMT), grooved pegboard test (GPT) and mini-mental state examination (MMSE). Generalized cognitive function was defined by a summary score calculated from the TMT and GPT. Linear regression was used to evaluate the associations between carotid atherosclerosis and cognitive function tests. Results: Larger IMT was associated with lower GPT, MMSE and the summary score adjusting for multiple factors, the coefficients were: 13.8s (p < 0.0001), -0.6 (p = 0.007), and 0.47 (p = 0.01), respectively for 1 mm increase in IMT. Plaque scores were significantly associated with TMT-B, GPT, MMSE, and the summary score adjusting for age, sex and education. The associations remained statistically significant after further adjustments except for the association with TMT-B, which was attenuated and no longer significant. Conclusions: Our results show the significant associations between markers of carotid atherosclerosis and cognitive function in a cohort of persons aged 21-84 years. Longitudinal studies are needed to further examine these associations. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.atherosclerosis.2011.07.013 http://hdl.handle.net/11536/14683 |
ISSN: | 0021-9150 |
DOI: | 10.1016/j.atherosclerosis.2011.07.013 |
期刊: | ATHEROSCLEROSIS |
Volume: | 219 |
Issue: | 1 |
起始頁: | 330 |
結束頁: | 333 |
顯示於類別: | 期刊論文 |