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dc.contributor.authorZhong, Wenjunen_US
dc.contributor.authorCruickshanks, Karen J.en_US
dc.contributor.authorHuang, Guan-Huaen_US
dc.contributor.authorKlein, Barbara E. K.en_US
dc.contributor.authorKlein, Ronalden_US
dc.contributor.authorNieto, F. Javieren_US
dc.contributor.authorPankow, James S.en_US
dc.contributor.authorSchubert, Carla R.en_US
dc.date.accessioned2014-12-08T15:20:39Z-
dc.date.available2014-12-08T15:20:39Z-
dc.date.issued2011-11-01en_US
dc.identifier.issn0021-9150en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.atherosclerosis.2011.07.013en_US
dc.identifier.urihttp://hdl.handle.net/11536/14683-
dc.description.abstractBackground: Atherosclerosis may be associated with cognitive function; however the studies are few, especially among midlife adults. Methods: Participants in the beaver dam offspring study who had cognitive test data and gradable carotid artery ultrasound scans were included (n = 2794, mean age: 49 years). Atherosclerosis was measured by carotid intima-media thickness (IMT) and the presence of plaque. Cognitive function was measured by the trail making test (TMT), grooved pegboard test (GPT) and mini-mental state examination (MMSE). Generalized cognitive function was defined by a summary score calculated from the TMT and GPT. Linear regression was used to evaluate the associations between carotid atherosclerosis and cognitive function tests. Results: Larger IMT was associated with lower GPT, MMSE and the summary score adjusting for multiple factors, the coefficients were: 13.8s (p < 0.0001), -0.6 (p = 0.007), and 0.47 (p = 0.01), respectively for 1 mm increase in IMT. Plaque scores were significantly associated with TMT-B, GPT, MMSE, and the summary score adjusting for age, sex and education. The associations remained statistically significant after further adjustments except for the association with TMT-B, which was attenuated and no longer significant. Conclusions: Our results show the significant associations between markers of carotid atherosclerosis and cognitive function in a cohort of persons aged 21-84 years. Longitudinal studies are needed to further examine these associations. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectAtherosclerosisen_US
dc.subjectCognitive functionen_US
dc.subjectEpidemiologyen_US
dc.titleCarotid atherosclerosis and cognitive function in midlife: The beaver dam offspring studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.atherosclerosis.2011.07.013en_US
dc.identifier.journalATHEROSCLEROSISen_US
dc.citation.volume219en_US
dc.citation.issue1en_US
dc.citation.spage330en_US
dc.citation.epage333en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.identifier.wosnumberWOS:000296587200050-
dc.citation.woscount10-
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