標題: | Base-Catalyzed Povarov Reaction: An Unusual [1,3] Sigmatropic Rearrangement to Dihydropyrimidobenzimidazoles |
作者: | Chen, Chih-Hau Yellol, Gorakh S. Lin, Po-Tsung Sun, Chung-Ming 應用化學系 Department of Applied Chemistry |
公開日期: | 7-十月-2011 |
摘要: | A novel base-catalyzed Povarov reaction of arylamines, aldehydes, and electron-deficient dienophiles has been developed. An unprecedented in situ [1,3] sigmatropic rearrangement leading to 4,10-dihydropyrimido[1,2-a]benzimidazoles has also been discovered. An insight of the plausible mechanism is discussed and supported by X-ray crystal study. This cascade reaction is achieved in a one-pot multicomponent fashion on soluble support under microwave conditions. |
URI: | http://dx.doi.org/10.1021/ol201985p http://hdl.handle.net/11536/14744 |
ISSN: | 1523-7060 |
DOI: | 10.1021/ol201985p |
期刊: | ORGANIC LETTERS |
Volume: | 13 |
Issue: | 19 |
起始頁: | 5120 |
結束頁: | 5123 |
顯示於類別: | 期刊論文 |