標題: Iterative alpha-Glycosylation Strategy for 2-Deoxy- and 2,6-Dideoxysugars: Application to the One-Pot Synthesis of Deoxysugar-Containing Oligosaccharides
作者: Chen, Jiun-Han
Ruei, Jyh-Herng
Mong, Kwok-Kong Tony
應用化學系
Department of Applied Chemistry
關鍵字: Carbohydrates;Oligosaccharides;Glycosylation
公開日期: 1-三月-2014
摘要: This paper describes the development of an iterative and -selective glycosylation method for 2-deoxyglycosyl and 2,6-dideoxythioglycoside donors based on the DMF modulation concept. We used NMR spectroscopy to probe the 2-deoxyglycosyl imidinium intermediate and elucidated the conditions to decrease the formation of glycal and thus to increase the reaction yields. Further elaboration of the glycosylation method opened the gate for an iterative one-pot synthesis of 2-deoxy- and 2,6-dideoxyglycoside-containing oligosaccharides.
URI: http://dx.doi.org/10.1002/ejoc.201400006
http://hdl.handle.net/11536/147675
ISSN: 1434-193X
DOI: 10.1002/ejoc.201400006
期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume: 2014
起始頁: 1827
結束頁: 1831
顯示於類別:期刊論文