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dc.contributor.authorChang, Chiao-Yunen_US
dc.contributor.authorLin, Hsiang-Tingen_US
dc.contributor.authorLai, Ming-Shengen_US
dc.contributor.authorShieh, Teng-Yien_US
dc.contributor.authorPeng, Chien-Chungen_US
dc.contributor.authorShih, Min-Hsiungen_US
dc.contributor.authorTung, Yi-Chungen_US
dc.date.accessioned2019-04-02T05:59:29Z-
dc.date.available2019-04-02T05:59:29Z-
dc.date.issued2018-08-07en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://dx.doi.org/10.1038/s41598-018-30180-8en_US
dc.identifier.urihttp://hdl.handle.net/11536/147971-
dc.description.abstractThe small sized, flexible, high-performed and bio-compatible sensing devices are the critical elements to realize the bio-related detection or on-site health monitoring systems. In this work, the flexible localized surface plasmon resonance (LSPR) bio-sensors were demonstrated by integrating the metal-insulator-metal (MIM) nanodisks with bio-compatible polydimethylsiloxane (PDMS) substrate. The different geometries of MIM nanodisk sensors were investigated and optimized to enhance the spatial overlap of the LSPR waves with the environment, which lead to a high sensitivity of 1500 nm/RIU. The omni-directional characteristics of LSPR resonances were beneficial for maintaining the device sensitivity stable under various bending curvatures. Furthermore, the flexible MIM nanodisk LSPR sensor was applied to detect A549 cancer cells in PBS+ solution. The absorption peak of the MIM-disk LSPR sensor obviously redshift to easily distinguish between the phosphate buffered saline (PBS+) solution with A549 cancer cells and without cells. Therefore, the flexible MIM nanodisk LSPR sensor is suitable to develop on-chip microfluidic biosensors for detection of cancer cells on nonplanar surfaces.en_US
dc.language.isoen_USen_US
dc.titleFlexible Localized Surface Plasmon Resonance Sensor with Metal-Insulator-Metal Nanodisks on PDMS Substrateen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-018-30180-8en_US
dc.identifier.journalSCIENTIFIC REPORTSen_US
dc.citation.volume8en_US
dc.identifier.wosnumberWOS:000440976700024en_US
dc.citation.woscount0en_US
Appears in Collections:Articles