標題: Biomimetic nano-surfactant stabilizes sub-50 nanometer phospholipid particles enabling high paclitaxel payload and deep tumor penetration
作者: Choi, Hoon
Liu, Ting
Qiao, Hui
Chacko, Ann-Marie
Hu, Shang-Hsiu
Chen, San-Yuan
Zhou, Rong
Chen, I-Wei
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Nano medicine;Drug delivery;Phospholipid;Liposomes;Fluid-gel transition;Surfactant;Micelle;Amphipathic peptides;Lipoproteins;Apolipoproteins;Paclitaxel;Breast cancer;Her-2
公開日期: 1-Oct-2018
摘要: Sub-50 nm nanoparticles feature long circulation and deep tumor penetration. However, at high volume fractions needed for intravenous injection, safe, highly biocompatible phospholipids cannot form such nanoparticles due to the fluidity of phospholipid shells. Here we overcome this challenge using a nano-surfactant, a sterilized 18-amino-acid biomimetic of the amphipathic helical motif abundant in HDL-apolipoproteins. As it induces a nanoscale phase (glass) transition in the phospholipid monolayer, the peptide stabilizes 5-7 nm phospholipid micelles that do not fuse at high concentrations but aggregate into stable micellesomes exhibiting size-dependent penetration into tumors. In mice bearing human Her-2-positive breast cancer xenografts, high-payload paclitaxel encapsulated in 25 nm (diameter) micellesomes kills more cancer cells than paclitaxel in standard clinical formulation, as evidenced by the enhanced apparent diffusion coefficient of water determined by in vivo MR imaging. Importantly, the bio-inertness of this biomimetic nano-surfactant spares the nanoparticles from being absorbed by liver hepatocytes, making them more generally available for drug delivery. (C) 2018 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.biomaterials.2018.07.034
http://hdl.handle.net/11536/148277
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2018.07.034
期刊: BIOMATERIALS
Volume: 181
起始頁: 240
結束頁: 251
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