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dc.contributor.authorChoi, Hoonen_US
dc.contributor.authorLiu, Tingen_US
dc.contributor.authorQiao, Huien_US
dc.contributor.authorChacko, Ann-Marieen_US
dc.contributor.authorHu, Shang-Hsiuen_US
dc.contributor.authorChen, San-Yuanen_US
dc.contributor.authorZhou, Rongen_US
dc.contributor.authorChen, I-Weien_US
dc.date.accessioned2019-04-02T06:00:29Z-
dc.date.available2019-04-02T06:00:29Z-
dc.date.issued2018-10-01en_US
dc.identifier.issn0142-9612en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.biomaterials.2018.07.034en_US
dc.identifier.urihttp://hdl.handle.net/11536/148277-
dc.description.abstractSub-50 nm nanoparticles feature long circulation and deep tumor penetration. However, at high volume fractions needed for intravenous injection, safe, highly biocompatible phospholipids cannot form such nanoparticles due to the fluidity of phospholipid shells. Here we overcome this challenge using a nano-surfactant, a sterilized 18-amino-acid biomimetic of the amphipathic helical motif abundant in HDL-apolipoproteins. As it induces a nanoscale phase (glass) transition in the phospholipid monolayer, the peptide stabilizes 5-7 nm phospholipid micelles that do not fuse at high concentrations but aggregate into stable micellesomes exhibiting size-dependent penetration into tumors. In mice bearing human Her-2-positive breast cancer xenografts, high-payload paclitaxel encapsulated in 25 nm (diameter) micellesomes kills more cancer cells than paclitaxel in standard clinical formulation, as evidenced by the enhanced apparent diffusion coefficient of water determined by in vivo MR imaging. Importantly, the bio-inertness of this biomimetic nano-surfactant spares the nanoparticles from being absorbed by liver hepatocytes, making them more generally available for drug delivery. (C) 2018 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectNano medicineen_US
dc.subjectDrug deliveryen_US
dc.subjectPhospholipiden_US
dc.subjectLiposomesen_US
dc.subjectFluid-gel transitionen_US
dc.subjectSurfactanten_US
dc.subjectMicelleen_US
dc.subjectAmphipathic peptidesen_US
dc.subjectLipoproteinsen_US
dc.subjectApolipoproteinsen_US
dc.subjectPaclitaxelen_US
dc.subjectBreast canceren_US
dc.subjectHer-2en_US
dc.titleBiomimetic nano-surfactant stabilizes sub-50 nanometer phospholipid particles enabling high paclitaxel payload and deep tumor penetrationen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.biomaterials.2018.07.034en_US
dc.identifier.journalBIOMATERIALSen_US
dc.citation.volume181en_US
dc.citation.spage240en_US
dc.citation.epage251en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000447111200017en_US
dc.citation.woscount0en_US
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