完整後設資料紀錄
DC 欄位語言
dc.contributor.authorLin, Chih-Wenen_US
dc.contributor.authorChen, Yaw-Senen_US
dc.contributor.authorLin, Chih-Cheen_US
dc.contributor.authorLee, Po-Huangen_US
dc.contributor.authorLo, Gin-Hoen_US
dc.contributor.authorHsu, Chia-Changen_US
dc.contributor.authorHsieh, Pei-Minen_US
dc.contributor.authorKoh, Kah Weeen_US
dc.contributor.authorChou, Tsung-Chingen_US
dc.contributor.authorDai, Chia-Yenen_US
dc.contributor.authorHuang, Jee-Fuen_US
dc.contributor.authorChuang, Wan-Longen_US
dc.contributor.authorChen, Yao-Lien_US
dc.contributor.authorYu, Ming-Lungen_US
dc.date.accessioned2019-04-02T05:59:44Z-
dc.date.available2019-04-02T05:59:44Z-
dc.date.issued2018-07-02en_US
dc.identifier.issn2155-384Xen_US
dc.identifier.urihttp://dx.doi.org/10.1038/s41424-018-0033-4en_US
dc.identifier.urihttp://hdl.handle.net/11536/148314-
dc.description.abstractBackground: The role of autophagy-related markers as the prognostic factor of post-operative hepatocellular carcinoma (HCC) recurrence remained controversial. Methods: Overall, 535 consecutive HCC patients undergoing curative resection from 2010 to 2014 were followed and classified with early (ER, < 2 years) or late recurrence (LR). Autophagy-related markers, LC3, Beclin-1, and p62 expression was immunohistochemically assessed in HCC and adjacent non-tumor (ANT) tissues. Results: HCC recurred in 245 patients: 116 with ER and 129 with LR. The cumulative incidence of recurrence at 1, 3, 5, and 7 years was 9.7%, 33.9%, 53.3%, and 66.3%, respectively. In multivariate analysis, HCC recurrence was significantly associated with low LC3 expression in tumor and ANT tissues, HCC tissues only and ANT tissues only (hazard ratio/95% confidence interval: 6.12/2.473-17.53, 4.18/1.285-13.61, and 1.89/1.299-2.757) and macrovascular invasion (1.63/1.043-2.492) and cirrhosis (1.59/1.088-2.326). ER was significantly associated with low LC3 expression in tumor and ANT tissues, HCC tissues only and ANT tissues only (6.54/2.934-15.81, 3.26/1.034-10.27, and 2.09/1.313-3.321) and macrovascular and microvascular invasion (2.65/1.306-5.343 and 2.55/1.177-5.504). LR was significantly associated with low LC3 expression in tumor and ANT tissues, HCC tissues only and ANT tissues only (5.02/1.372-18.83, 3.19/1.13-12.09, and 1.66/1.051-2.620) and cirrhosis (1.66/1.049-2.631). Patients with low and high LC3 expression in tumor and ANT tissues showed a 5-year cumulative recurrence of 94.3% and 41.7%, respectively (p < 0.001). Conclusions: The high LC3 expression in the tumor and liver microenvironments is significantly associated with lower HCC recurrence. Furthermore, tumor characteristics and liver microenvironment were also significantly associated with ER and LR, respectively. Translational impact: The analysis for LC3 expression in both the HCC and ANT tissues could identify patients at risk of HCC recurrence.en_US
dc.language.isoen_USen_US
dc.titleAutophagy-related gene LC3 expression in tumor and liver microenvironments significantly predicts recurrence of hepatocellular carcinoma after surgical resectionen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41424-018-0033-4en_US
dc.identifier.journalCLINICAL AND TRANSLATIONAL GASTROENTEROLOGYen_US
dc.citation.volume9en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.identifier.wosnumberWOS:000447535900002en_US
dc.citation.woscount1en_US
顯示於類別:期刊論文