標題: Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats
作者: Sung, Yen-Ling
Wu, Chih-En
Syu, Jhen-Yang
Kuo, Terry B. J.
Li, Jai-Yi
Chen, Chieh-Wen
Weng, Ching-Hui
Hsu, Wei-Hsuan
Chen, Shih-Ann
Hu, Yu-Feng
Lin, Shien-Fong
交大名義發表
National Chiao Tung University
關鍵字: Spontaneously hypertensive rat;Exercise;Ventricular tachycardia;Heart rate variability
公開日期: 1-十一月-2018
摘要: Chronic hypertension is a multifactorial disease that is highly associated with cardiovascular disorders. Physical activity, such as long-term exercise, is advocated as a treatment for hypertension, but the responses of different age groups to long-term exercise are unknown. We used aged spontaneous hypertensive rats (SHRs, 80 weeks old) to test the hypothesis that long-term exercise compensated for deficient autonomic control and reduced susceptibility to ventricular tachycardia (VT) and ventricular fibrillation (VF) in this animal model. The aged SHRs were divided into control and voluntary exercise groups. Ambulatory electrocardiography was recorded for the heart rate variability (HRV) analysis. Programmed stimulation was applied to exposed hearts to induce ventricular arrhythmia in situ. Then, the hearts were isolated for an optical mapping study. The results showed that increased HRV indices were broadly related to vagal dominance in the high-intensity exercise group. Exercise altered the electrical propagation dynamic properties, such as the action potential duration restitution (APDR). Furthermore, the VF inducibility decreased with increased exercise intensity. Taken together, our results suggest that long-term exercise reduces the risk of arrhythmogenesis in aged SHRs through enhanced vagal control and stabilized electrical dynamics.
URI: http://dx.doi.org/10.1016/j.compbiomed.2018.08.016
http://hdl.handle.net/11536/148444
ISSN: 0010-4825
DOI: 10.1016/j.compbiomed.2018.08.016
期刊: COMPUTERS IN BIOLOGY AND MEDICINE
Volume: 102
起始頁: 390
結束頁: 395
顯示於類別:期刊論文