標題: Interactions of BDNF Val66Met Polymorphism and Menstrual Pain on Brain Complexity
作者: Low, Intan
Kuo, Po-Chih
Tsai, Cheng-Lin
Liu, Yu-Hsiang
Lin, Ming-Wei
Chao, Hsiang-Tai
Chen, Yong-Sheng
Hsieh, Jen-Chuen
Chen, Li-Fen
交大名義發表
資訊工程學系
National Chiao Tung University
Department of Computer Science
關鍵字: BDNF Val66Met polymorphism;primary dysmenorrhea;brain complexity;multiscale entropy;magnetoencephalography;chronic pain
公開日期: 20-十一月-2018
摘要: The irregularity and uncertainty of neurophysiologic signals across different time scales can be regarded as neural complexity, which is related to the adaptability of the nervous system and the information processing between neurons. We recently reported general loss of brain complexity, as measured by multiscale sample entropy (MSE), at pain-related regions in females with primary dysmenorrhea (PDM). However, it is unclear whether this loss of brain complexity is associated with inter-subject genetic variations. Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin in the brain and is crucial to neural plasticity. The BDNF Val66Met single-nucleotide polymorphism (SNP) is associated with mood, stress, and pain conditions. Therefore, we aimed to examine the interactions of BDNF Val66Met polymorphism and long-term menstrual pain experience on brain complexity. We genotyped BDNF Val66Met SNP in 80 PDM females (20 Val/Val, 31 Val/Met, 29 Met/Met) and 76 healthy female controls (25 Val/Val, 36 Val/Met, 15 Met/Met). MSE analysis was applied to neural source activity estimated from resting-state magnetoencephalography (MEG) signals during pain-free state. We found that brain complexity alterations were associated with the interactions of BDNF Val66Met polymorphism and menstrual pain experience. In healthy female controls, Met carriers (Val/Met and Met/Met) demonstrated lower brain complexity than Val/Val homozygotes in extensive brain regions, suggesting a possible protective role of Val/Val homozygosity in brain complexity. However, after experiencing long-term menstrual pain, the complexity differences between different genotypes in healthy controls were greatly diminished in PDM females, especially in the limbic system, including the hippocampus and amygdala. Our results suggest that pain experience preponderantly affects the effect of BDNF Val66Met polymorphism on brain complexity. The results of the present study also highlight the potential utilization of resting-state brain complexity for the development of new therapeutic strategies in patients with chronic pain.
URI: http://dx.doi.org/10.3389/fnins.2018.00826
http://hdl.handle.net/11536/148486
ISSN: 1662-453X
DOI: 10.3389/fnins.2018.00826
期刊: FRONTIERS IN NEUROSCIENCE
Volume: 12
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