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dc.contributor.authorHuang, Yun-Anen_US
dc.contributor.authorHo, Chris T.en_US
dc.contributor.authorLin, Yu-Hsuanen_US
dc.contributor.authorLee, Chen-Juen_US
dc.contributor.authorHo, Szu-Moen_US
dc.contributor.authorLi, Ming-Chiaen_US
dc.contributor.authorHwang, Ericen_US
dc.date.accessioned2019-04-02T05:58:09Z-
dc.date.available2019-04-02T05:58:09Z-
dc.date.issued2018-12-01en_US
dc.identifier.issn1616-5187en_US
dc.identifier.urihttp://dx.doi.org/10.1002/mabi.201800335en_US
dc.identifier.urihttp://hdl.handle.net/11536/148574-
dc.description.abstractSurface topography has a profound effect on the development of the nervous system, such as neuronal differentiation and morphogenesis. While the interaction of neurons and the surface topography of their local environment is well characterized, the neuron-topography interaction during the regeneration process remains largely unknown. To address this question, an anisotropic surface topography resembling linear grooves made from poly(ethylene-vinyl acetate) (EVA), a soft and biocompatible polymer, using nanoimprinting, is established. It is found that neurons from both the central and peripheral nervous system can survive and grow on this grooved surface. Additionally, it is observed that axons but not dendrites specifically align with these grooves. Furthermore, it is demonstrated that neurons on the grooved surface are capable of regeneration after an on-site injury. More importantly, these injured neurons have an accelerated and enhanced regeneration. Together, the data demonstrate that this anisotropic topography guides axon growth and improves axon regeneration. This opens up the possibility to study the effect of surface topography on regenerating axons and has the potential to be developed into a medical device for treating peripheral nerve injuries.en_US
dc.language.isoen_USen_US
dc.subjectmicrofabricated substratum nerve regenerationen_US
dc.subjectneurite guidanceen_US
dc.subjecttissue engineeringen_US
dc.subjecttopographic guidanceen_US
dc.titleNanoimprinted Anisotropic Topography Preferentially Guides Axons and Enhances Nerve Regenerationen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/mabi.201800335en_US
dc.identifier.journalMACROMOLECULAR BIOSCIENCEen_US
dc.citation.volume18en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000452525800011en_US
dc.citation.woscount0en_US
Appears in Collections:Articles