Title: | The Implementation of a Low-Power Biomedical Signal Processor for Real-Time Epileptic Seizure Detection on Absence Animal Models |
Authors: | Chen, Tsan-Jieh Chiueh, Herming Liang, Sheng-Fu Chang, Shun-Ting Jeng, Chi Hsu, Yu-Cheng Chien, Tzu-Chieh 電子工程學系及電子研究所 Department of Electronics Engineering and Institute of Electronics |
Keywords: | Electroencephalogram (EEG);epilepsy;reduced instruction set computer (RISC);seizure detection |
Issue Date: | 1-Dec-2011 |
Abstract: | Epilepsy is one of the most common neurological disorders, with a worldwide prevalence of approximately 1%. A considerable portion of epilepsy patients cannot be treated sufficiently by today's available therapies. Implantable closed-loop neurostimulation is an innovative and effective method for seizure control. A real-time seizure detector is the kernel of a closed-loop seizure controller. In this paper, a low-power biomedical signal processor based on reduced instruction set computer (RISC) architecture for real-time seizure detection is implemented to achieve low-power consumption and perform continuous and real-time processing. The low-power processor is implemented in a 0.18 mu m complementary-metal-oxide semiconductor technology to verify functionality and capability. The measurement results show the implemented processor can reduce over 90% power consumption compared with our previous prototype, which was implemented on an enhanced 8051 microprocessor. This seizure detector was applied to the continuous EEG signals of four Long-Evans rats with spontaneous absence seizures. It also processed 24 h long-term and uninterrupted EEG sequence. The developed seizure detector can be applied for online seizure monitoring and integrated with an electrical stimulator to perform a closed-loop seizure controller in the future. |
URI: | http://dx.doi.org/10.1109/JETCAS.2011.2174472 http://hdl.handle.net/11536/148734 |
ISSN: | 2156-3357 |
DOI: | 10.1109/JETCAS.2011.2174472 |
Journal: | IEEE JOURNAL ON EMERGING AND SELECTED TOPICS IN CIRCUITS AND SYSTEMS |
Volume: | 1 |
Begin Page: | 613 |
End Page: | 621 |
Appears in Collections: | Articles |