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dc.contributor.authorChang, Jenny Zwei-Chiengen_US
dc.contributor.authorTsai, Pei-Ien_US
dc.contributor.authorKuo, Mark Yen-Pingen_US
dc.contributor.authorSun, Jui-Shengen_US
dc.contributor.authorChen, San-Yuanen_US
dc.contributor.authorShen, Hsin-Hsinen_US
dc.date.accessioned2019-04-02T06:00:49Z-
dc.date.available2019-04-02T06:00:49Z-
dc.date.issued2019-01-01en_US
dc.identifier.issn1996-1944en_US
dc.identifier.urihttp://dx.doi.org/10.3390/ma12010164en_US
dc.identifier.urihttp://hdl.handle.net/11536/148749-
dc.description.abstractA mismatch of elastic modulus values could result in undesirable bone resorption around the dental implant. The objective of this study was to optimize direct metal laser sintering (DMLS)-manufactured Ti6Al4V dental implants' design, minimize elastic mismatch, allow for maximal bone ingrowth, and improve long-term fixation of the implant. In this study, DMLS dental implants with different morphological characteristics were fabricated. Three-point bending, torsional, and stability tests were performed to compare the mechanical properties of different designs. Improvement of the weaker design was attempted by augmentation with a longitudinal 3D-printed strut. The osseointegrative properties were evaluated. The results showed that the increase in porosity decreased the mechanical properties, while augmentation with a longitudinal weight-bearing strut can improve mechanical strength. Maximal alkaline phosphatase gene expression of MG63 cells attained on 60% porosity Ti6Al4V discs. In vivo experiments showed good incorporation of bone into the porous scaffolds of the DMLS dental implant, resulting in a higher pull-out strength. In summary, we introduced a new design concept by augmenting the implant with a longitudinal weight-bearing strut to achieve the ideal combination of high strength and low elastic modulus; our results showed that there is a chance to reach the balance of both biologic and mechanical demands.en_US
dc.language.isoen_USen_US
dc.subjectdirect metal laser sinteringen_US
dc.subjectbiomimeticen_US
dc.subjectporous titaniumen_US
dc.subjectTi6Al4Ven_US
dc.subject3D-printingen_US
dc.titleAugmentation of DMLS Biomimetic Dental Implants with Weight-Bearing Strut to Balance of Biologic and Mechanical Demands: From Bench to Animalen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ma12010164en_US
dc.identifier.journalMATERIALSen_US
dc.citation.volume12en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.identifier.wosnumberWOS:000456410200164en_US
dc.citation.woscount0en_US
Appears in Collections:Articles