完整後設資料紀錄
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dc.contributor.authorLu, Yen-Chuen_US
dc.contributor.authorMondal, Soumiken_US
dc.contributor.authorWang, Ching-Chien_US
dc.contributor.authorLin, Chun-Hungen_US
dc.contributor.authorMong, Kwok-Kong Tonyen_US
dc.date.accessioned2019-04-02T06:00:27Z-
dc.date.available2019-04-02T06:00:27Z-
dc.date.issued2019-01-18en_US
dc.identifier.issn1439-4227en_US
dc.identifier.urihttp://dx.doi.org/10.1002/cbic.201800656en_US
dc.identifier.urihttp://hdl.handle.net/11536/148820-
dc.description.abstractA general strategy for the diverse synthesis of ten disaccharide aminoglycosides, including natural 2-trehalosamine (1), 3-trehalosamine (2), 4-trehalosamine (3), and neotrehalosyl 3,3 '-diamine (8) and synthetic aminoglycosides 4-7, 9, and 10, has been developed. The aminoglycoside compounds feature different anomeric configurations and numbers of amino groups. The key step for the synthesis was the glycosylation coupling of a stereodirecting donor with a configuration-stable TMS glycoside acceptor. Either the donor or acceptor could be substituted with an azido group. The aminoglycosides prepared in the present study were characterized by 1D and 2D NMR spectroscopy.en_US
dc.language.isoen_USen_US
dc.subjectdisaccharidesen_US
dc.subjectaminoglycosidesen_US
dc.subjectglycosylationen_US
dc.subjectprotecting groupsen_US
dc.subjecttrimethylsilyl glycoside acceptorsen_US
dc.titleDiverse Synthesis of Natural Trehalosamines and Synthetic 1,1 '-Disaccharide Aminoglycosidesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/cbic.201800656en_US
dc.identifier.journalCHEMBIOCHEMen_US
dc.citation.volume20en_US
dc.citation.spage287en_US
dc.citation.epage294en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000457615700023en_US
dc.citation.woscount0en_US
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