標題: | Direct Access to Dihydrobenzoimidazo[2,1-a]isoquinolines through Ruthenium-catalyzed Formal [4+2] Annulation |
作者: | Dhole, Sandip Sun, Chung-Ming 應用化學系 Department of Applied Chemistry |
關鍵字: | Benzoimidazo[2,1-a]isoquinolines Ruthenium;[4+2] annulation;2-aryl benzimidazole;Styrene |
公開日期: | 1-二月-2019 |
摘要: | A facile and straightforward synthesis of benzoimidazo[2,1-a]isoquinolines through Ru(II)-catalyzed [4+2] annulation reaction of 2-aryl benzimidazole and styrene has been explored. Tentative mechanistic studies imply the current reaction involves sequential C-C/C-N bond formation through the ortho C-H activation of 2-aryl benzimidazole followed by C-N reductive elimination. This newly developed strategy is widely applicable and tolerates various 2-arylbenzimidazole and vinyl derivatives, and allows the attractive vehicle for direct construction of diverse C6-substituated benzoimidazoisoquinoline scaffold in good yields. |
URI: | http://dx.doi.org/10.1002/adsc.201801241 http://hdl.handle.net/11536/148827 |
ISSN: | 1615-4150 |
DOI: | 10.1002/adsc.201801241 |
期刊: | ADVANCED SYNTHESIS & CATALYSIS |
Volume: | 361 |
起始頁: | 535 |
結束頁: | 541 |
顯示於類別: | 期刊論文 |