標題: Direct Access to Dihydrobenzoimidazo[2,1-a]isoquinolines through Ruthenium-catalyzed Formal [4+2] Annulation
作者: Dhole, Sandip
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Benzoimidazo[2,1-a]isoquinolines Ruthenium;[4+2] annulation;2-aryl benzimidazole;Styrene
公開日期: 1-二月-2019
摘要: A facile and straightforward synthesis of benzoimidazo[2,1-a]isoquinolines through Ru(II)-catalyzed [4+2] annulation reaction of 2-aryl benzimidazole and styrene has been explored. Tentative mechanistic studies imply the current reaction involves sequential C-C/C-N bond formation through the ortho C-H activation of 2-aryl benzimidazole followed by C-N reductive elimination. This newly developed strategy is widely applicable and tolerates various 2-arylbenzimidazole and vinyl derivatives, and allows the attractive vehicle for direct construction of diverse C6-substituated benzoimidazoisoquinoline scaffold in good yields.
URI: http://dx.doi.org/10.1002/adsc.201801241
http://hdl.handle.net/11536/148827
ISSN: 1615-4150
DOI: 10.1002/adsc.201801241
期刊: ADVANCED SYNTHESIS & CATALYSIS
Volume: 361
起始頁: 535
結束頁: 541
顯示於類別:期刊論文