標題: Palladium-catalyzed N1-selective allylation of indoles with allylic alcohols promoted by titanium tetraisopropoxide
作者: Chang, Chieh-Yu
Lin, Yu-Huan
Wu, Yen-Ku
應用化學系
Department of Applied Chemistry
公開日期: 25-Jan-2019
摘要: The direct N1-selective allylation of indoles with allylic alcohols has been accomplished by synergistic functions of palladium catalysts and titanium tetraisopropoxide. The site selectivity is notably different from that observed in other related transition metal-catalyzed approaches. This chemistry provides a facile route to a variety of allylated indoles in synthetically useful yields. The utility of this simple allylation reaction was demonstrated with the first total synthesis of (+)-N-(4-hydroxyprenyl)-cyclo(alanyltryptophyl), which was completed in five steps, starting from l-tryptophan methyl ester hydrochloride.
URI: http://dx.doi.org/10.1039/c8cc09817d
http://hdl.handle.net/11536/148864
ISSN: 1359-7345
DOI: 10.1039/c8cc09817d
期刊: CHEMICAL COMMUNICATIONS
Volume: 55
起始頁: 1116
結束頁: 1119
Appears in Collections:Articles