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dc.contributor.authorChang, Koen_US
dc.contributor.authorLee, Nan-Yaoen_US
dc.contributor.authorKo, Wen-Chienen_US
dc.contributor.authorLin, Wei-Ruen_US
dc.contributor.authorChen, Yen-Hsuen_US
dc.contributor.authorTsai, Jih-Jinen_US
dc.contributor.authorChen, Tun-Chiehen_US
dc.contributor.authorLin, Chun-Yuen_US
dc.contributor.authorChang, Ya-Tingen_US
dc.contributor.authorLu, Po-Liangen_US
dc.date.accessioned2019-04-02T05:58:01Z-
dc.date.available2019-04-02T05:58:01Z-
dc.date.issued2019-02-01en_US
dc.identifier.issn1684-1182en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jmii.2016.08.023en_US
dc.identifier.urihttp://hdl.handle.net/11536/148870-
dc.description.abstractBackground/purpose: The clinical manifestations of scrub typhus, murine typhus and acute Q fever in the elderly are not clear. Methods: We conducted a retrospective study to identify the characteristics of the elderly aged >= 65 years with a comparison group aged 18-64 years among patients with scrub typhus, murine typhus, or acute Q fever who were serologically confirmed at three hospitals in Taiwan during 2002-2011. Results: Among 441 cases, including 187 cases of scrub typhus, 166 acute Qfever, and 88 murine typhus, 68 (15.4%) cases were elderly patients. The elderly had a higher severe complication rate (10.3% vs. 3.5%, p = 0.022), but did not have a significantly higher mortality rate (1.47% vs. 0.54%, p = 0.396). Compared with those without severe complications, we found the elderly (p = 0.022), dyspnea (p = 0.006), less relative bradycardia (p = 0.004), less febrile illness (p = 0.004), prolonged prothrombin time (PT) (p = 0.002), higher levels of initial C-reactive protein (p = 0.039), blood leukocyte counts (p = 0.01), and lower platelet counts (p = 0.012) are significantly associated with severe complications. Only prolonged prothrombin time was associated with severe complications in multivariate analysis (p = 0.018, CI 95% 0.01-0.66). Among clinical symptoms and laboratory data, multivariate analysis revealed chills was less frequently occurred in the elderly (p = 0.012, 95% confidence interval [CI]: 1.33-9.99). Conclusion: The elderly cases with scrub typhus, murine typhus, or acute Q fever would be more likely to have severe complications, for which prothrombin time prolongation is an important predictor for severe complications. Copyright (C) 2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.en_US
dc.language.isoen_USen_US
dc.subjectElderlyen_US
dc.subjectScrub typhusen_US
dc.subjectAcute Q feveren_US
dc.subjectMurine typhusen_US
dc.subjectComplicationsen_US
dc.titleCharacteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severityen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jmii.2016.08.023en_US
dc.identifier.journalJOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTIONen_US
dc.citation.volume52en_US
dc.citation.spage54en_US
dc.citation.epage61en_US
dc.contributor.department生醫工程研究所zh_TW
dc.contributor.departmentInstitute of Biomedical Engineeringen_US
dc.identifier.wosnumberWOS:000458620500007en_US
dc.citation.woscount1en_US
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