標題: Synthesis, Isolation, and Characterization of Mono- and Bis-norbornene-Annulated Biarylamines through Pseudo-Catellani Intermediates
作者: Annamalai, Pratheepkumar
Hsiao, Huan-Chang
Raju, Selvam
Fu, Yi-Hsuan
Chen, Pei-Ling
Horng, Jia-Cherng
Liu, Yi-Hung
Chuang, Shih-Ching
應用化學系
Department of Applied Chemistry
公開日期: 15-Feb-2019
摘要: A palladium-catalyzed C-H functionalization of an external ring of N-acyl 2-aminobiaryl with bicyclo[2.2.1]-hept-2-ene (norbornene) via multiple C-H bond activations was developed. This study is the first report of the formation of bis-norbornene annulated biarylamines isomers (syn-3a'/anti-3a' = 36:64) from multiple C-H bond functionalizations. Additionally, nondirected C-H bond functionalization at the C-4' position with alkenes rendered complete C-H functionalization of five C-H bonds that formed a stable hexasubstituted benzene ring.
URI: http://dx.doi.org/10.1021/acs.orglett.9b00119
http://hdl.handle.net/11536/148901
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.9b00119
期刊: ORGANIC LETTERS
Volume: 21
起始頁: 1182
結束頁: 1186
Appears in Collections:Articles