標題: Reversed ophthalmic artery flow following ischemic stroke: a possible predictor of outcomes following carotid artery stenting
作者: Lin, Chih-Ming
Liu, Chi-Kuang
Chang, Yu-Jun
Chen, Wei-Liang
Lu, Henry Horng-Shing
統計學研究所
大數據研究中心
Institute of Statistics
Big Data Res Ctr
關鍵字: Ischemic stroke;ophthalmic artery;modified Rankin scale;Barthel Index;C-reactive protein;carotid duplex
公開日期: 1-Jan-2019
摘要: Stroke is the leading cause of death worldwide and stenosis of the carotid artery accounts for more than half of all cases. Carotid duplex is an effective non-invasive ultrasound test which identifies stroke patients with moderate to severe carotid stenosis who are candidates for preventative intervention to reduce the risk of recurrence. In patients with moderate to severe carotid stenosis, reversed ophthalmic artery flow (ROAF) is often observed at the time of the carotid duplex scan. In this study, we investigated whether ROAF, denoting exhaustion of cerebral collateral flow in ischemic stroke patients affected mid-term functional outcomes following carotid artery stenting (CAS) procedures. In total, 144 consecutive patients with a first episode of ischemic stroke and subsequent CAS procedure conducted between January 2010 and November 2014 at Changhua Christian Hospital, Taiwan were included. Clinical data were obtained by medical record review. Disability was assessed at two time points by utilising the Barthel Index (BI) and modified Rankin Scale (mRS) before CAS and 12 months post-CAS. Among 85 patients presenting without ROAF, 48/85 (56.4%) had improved mRS scores following stenting. The condition remained unchanged (stationary) in 36/85 (43.3%) patients after stenting and one patient exhibited deteriorated condition 1/85(1.1%). In contrast, among the 59 patients presenting with ROAF, 24/59 (40.6%) had improved mRS score following stenting. The condition remained unchanged (stationary) in the remaining 35/59 (59.3%) patients after stenting, and no patient exhibited deteriorated condition 0/ 59 (0 %). This study provides evidence that CAS is a valid and effective treatment option regardless of whether patients exhibited ROAF or not. Patients without ROAF were significantly more likely to have improved mid-term functional outcomes compared to those with ROAF. In the group without ROAF admission, CRP may play a role in predicting subsequent functional outcomes, whereas admission Barthel Index was a predictor of outcome in the ROAF group.
URI: http://dx.doi.org/10.1080/01616412.2018.1544744
http://hdl.handle.net/11536/148912
ISSN: 0161-6412
DOI: 10.1080/01616412.2018.1544744
期刊: NEUROLOGICAL RESEARCH
Volume: 41
起始頁: 132
結束頁: 138
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