Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Juang, J. -H. | en_US |
dc.contributor.author | Tu, C. -F. | en_US |
dc.contributor.author | Kuo, C. -H. | en_US |
dc.date.accessioned | 2014-12-08T15:21:04Z | - |
dc.date.available | 2014-12-08T15:21:04Z | - |
dc.date.issued | 2011-11-01 | en_US |
dc.identifier.issn | 0041-1345 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1016/j.transproceed.2011.09.097 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/14982 | - |
dc.description.abstract | Interactions of Fas with its ligand (FasL) play an important role in the maintenance of immunologic homeostasis and peripheral tolerance. Heme oxygenase-1 (HO-1) is a protein capable of cytoprotection via radical scavenging and apoptosis prevention. The aim of this study was to test whether overexpression of FasL and HO-1 in murine islets resulted in cell protection and improved functional performance after transplantation. We first generated FasL and HO-1 double transgenic mice to investigate the protective effect of transgenic islets on transplantation. Islets were isolated from FasL and HO-1 double transgenic and nontransgenic Balb/c mice, for transplantation of 300 islets under the left kidney capsule of each streptozotocin-diabetic Balb/c mouse. During 6 weeks after transplantation, the blood glucose gradually decreased in recipients of double transgenic and nontransgenic islets. However, the decrease in blood glucose was more pronounced in the former (450 +/- 16 mg/dL at day 0 to 302 +/- 55 mg/dL at day 42; P =.01) than the latter (468 +/- 17 mg/dL at day 0 to 379 +/- 71 mg/dL at day 42; P =.24). The areas under the curve of intraperitoneal glucose tolerance tests at 2, 4, and 6 weeks were not significantly different between recipients of double transgenic and nontransgenic islets. The body weight increased in recipients of double transgenic islets (21.1 +/- 1.4 g at day 0 to 26.2 +/- 0.8 g at day 42; P =.0002) and nontransgenic islets (21.0 +/- 1.4 g at day 0 to 25.1 +/- 0.4 g at day 42; P =.0448). Our data suggested modest beneficial effects of transgenic islets with FasL and HO-1 overexpression for transplantation. | en_US |
dc.language.iso | en_US | en_US |
dc.title | Modest Effects of Fas-Ligand and Heme Oxygenase-1 Double Transgenic Mouse Islets on Transplantation Outcomes | en_US |
dc.type | Article; Proceedings Paper | en_US |
dc.identifier.doi | 10.1016/j.transproceed.2011.09.097 | en_US |
dc.identifier.journal | TRANSPLANTATION PROCEEDINGS | en_US |
dc.citation.volume | 43 | en_US |
dc.citation.issue | 9 | en_US |
dc.citation.spage | 3198 | en_US |
dc.citation.epage | 3200 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.identifier.wosnumber | WOS:000297485500013 | - |
Appears in Collections: | Conferences Paper |
Files in This Item:
If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.