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dc.contributor.authorChen, Wei-Jenen_US
dc.contributor.authorChen, Yu-Chieen_US
dc.date.accessioned2019-04-02T05:59:56Z-
dc.date.available2019-04-02T05:59:56Z-
dc.date.issued2010-12-01en_US
dc.identifier.issn1743-5889en_US
dc.identifier.urihttp://dx.doi.org/10.2217/NNM.10.92en_US
dc.identifier.urihttp://hdl.handle.net/11536/150229-
dc.description.abstractAims: We demonstrate a photokilling approach for pathogenic bacteria using magnetic nanoparticles as photokilling nanoprobes. Materials & methods: The nanoprobes are composed of iron oxide/titania (Fe3O4/TiO2) core/shell magnetic nanoparticles. The titanium layer on the magnetic nanoprobes plays two roles: as a photokilling agent and as an affinity substrate for pathogenic bacteria. The magnetic property of the nanoprobes allows the resultant nanoprobe-target species conjugates to be readily aggregated at a small spot under external magnetic field for conducting photokilling treatment. Therefore, damage to nontarget cells can be reduced. Results: The results show that Fe3O4/TiO2 core/shell magnetic nanoparticles do not only have the capacity to target pathogenic bacteria, including Gram-negative, Gram-positive and antibiotic-resistant bacteria, but they can also be used to effectively inhibit the cell growth of the bacteria (>99.9%) targeted by the magnetic nanoparticles under irradiation of a low-power UV lamp (lambda(max) similar to 306 nm, 0.412 mW/cm(2)) within 15 min. Conclusion: The potential application of this approach is in the treatment of cutaneous bacterial infections.en_US
dc.language.isoen_USen_US
dc.subjectantibiotic-resistanten_US
dc.subjectmagnetic nanoparticlesen_US
dc.subjectpathogenic bacteriaen_US
dc.subjectphotokillingen_US
dc.subjecttitaniaen_US
dc.titleFe3O4/TiO2 core/shell magnetic nanoparticle-based photokilling of pathogenic bacteriaen_US
dc.typeArticleen_US
dc.identifier.doi10.2217/NNM.10.92en_US
dc.identifier.journalNANOMEDICINEen_US
dc.citation.volume5en_US
dc.citation.spage1585en_US
dc.citation.epage1593en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000286541700013en_US
dc.citation.woscount21en_US
Appears in Collections:Articles