完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen, Po-Jung | en_US |
dc.contributor.author | Hu, Shang-Hsiu | en_US |
dc.contributor.author | Hsiao, Chi-Sheng | en_US |
dc.contributor.author | Chen, You-Yin | en_US |
dc.contributor.author | Liu, Dean-Mo | en_US |
dc.contributor.author | Chen, San-Yuan | en_US |
dc.date.accessioned | 2019-04-02T05:59:55Z | - |
dc.date.available | 2019-04-02T05:59:55Z | - |
dc.date.issued | 2011-01-01 | en_US |
dc.identifier.issn | 0959-9428 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1039/c0jm02590a | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/150245 | - |
dc.description.abstract | In this study, a novel nanocarrier (MSN@Fe3O4) is constructed using a facile technology by capping mesoporous silica nanoparticles (MSN) with monodispersed Fe3O4 nanoparticles through chemical bonding. The chemical links provide adhesion, which permits the magnetic nanoparticles, as nano-caps, to efficiently cover the mesoporous pores on the mesoporous silica matrix and be tightly bonded with the matrix surface. Without magnetic stimulus, none or only a negligible amount of the drug can be released from the MSN@Fe3O4. However, when subjected to an external controllable magnetic field, a quantity of nano-caps can be remotely and precisely removed, giving tunable release profiles for an anticancer drug, (S)-(+)-camptothecin (CPT), with various dosages depending upon the strength and time period of magnetic induction. The transverse relaxivity (r(2)) of the MSN@Fe3O4 nanocarriers was measured to be about 121.57 s(-1)mM(-1) Fe, which is larger than that for the reported mesoporous silica nanoparticles decorated with magnetite nanocrystals. Therefore, MSN@Fe3O4 nanocarriers could perform well as T-2-type MR contrast enhancement agents for cell or molecular imaging. In addition, the MSN@Fe3O4 nanocarriers also demonstrate fairly high cell uptake efficiency. Together with its versatile magnetic manipulation, this new type of MSN@Fe3O4 nanosystem can be considered as a new class of multifunctional nanodevice, with combined tunable drug release and nanoimaging modalities for a variety of biomedical uses. | en_US |
dc.language.iso | en_US | en_US |
dc.title | Multifunctional magnetically removable nanogated lids of Fe3O4-capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1039/c0jm02590a | en_US |
dc.identifier.journal | JOURNAL OF MATERIALS CHEMISTRY | en_US |
dc.citation.volume | 21 | en_US |
dc.citation.spage | 2535 | en_US |
dc.citation.epage | 2543 | en_US |
dc.contributor.department | 材料科學與工程學系 | zh_TW |
dc.contributor.department | Department of Materials Science and Engineering | en_US |
dc.identifier.wosnumber | WOS:000287092000020 | en_US |
dc.citation.woscount | 75 | en_US |
顯示於類別: | 期刊論文 |