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dc.contributor.authorShen, Chien-Hungen_US
dc.contributor.authorTseng, Chih-Chungen_US
dc.contributor.authorTasi, Cheng-Hsunen_US
dc.contributor.authorShintre, Suhas A.en_US
dc.contributor.authorChen, Li-Hsunen_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2019-04-02T05:58:16Z-
dc.date.available2019-04-02T05:58:16Z-
dc.date.issued2012-05-06en_US
dc.identifier.issn0040-4020en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.tet.2012.03.015en_US
dc.identifier.urihttp://hdl.handle.net/11536/150454-
dc.description.abstractA novel protocol for rapid assemble of quinoxalinones framework has been demonstrated. This method incorporated with soluble polymer support provides a convenient approach for diversification of heterocyclic compounds and for easy purification via facile precipitation from reaction matrix. The key transformation of this study involves in situ reduction of aromatic nitro compound, tandem lactamization concomitant with traceless cleavage of the polymer support under microwave irradiation in a one-pot fashion. Moreover, forward synthetic routes were introduced to maximize complexity of the master intermediate on which further chemical elaboration was applied. The strategy is envisaged to apply for establishment of drug-like small-molecule libraries for high-throughput screening. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.titleTraceless polymer-supported divergent synthesis of quinoxalinones by microwave irradiationen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.tet.2012.03.015en_US
dc.identifier.journalTETRAHEDRONen_US
dc.citation.volume68en_US
dc.citation.spage3532en_US
dc.citation.epage3540en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000303303600002en_US
dc.citation.woscount3en_US
Appears in Collections:Articles