標題: | DRUG COMPOSITION AND METHOD FOR PREPARING THE SAME |
作者: | Wei-Ting Huang Yi-Chi Lee Dean-Mo Liu |
公開日期: | 2-二月-2017 |
摘要: | The present invention provides a method for preparing a drug composition, which includes steps of dispersing an amphiphilic chitosan derivative, at least a hydrophobic drug, and at least a hydrophilic drug into a solvent to form a mixture solution, and the pH value of the mixture solution is adjusted to a range without precipitating the hydrophilic drug(s) and the hydrophobic drug(s), wherein the amphiphilic chitosan derivative is modified by a plurality of hydrophilic group(s) and a plurality of hydrophobic group(s); and after stirring the mixture solution for at least 12 hours, receiving the drug composition when the pH value of the mixture solution is between pH 6 to 7. The hydrophilic drug(s) and the hydrophobic drug(s) are encapsulated simultaneously by one-pot synthesis, and the protein could be modified by one-pot synthesis to provide a drug composition with multiple functions. |
官方說明文件#: | A61K009/51 A61K047/48 A61K047/36 A61K033/24 A61K031/12 |
URI: | http://hdl.handle.net/11536/151248 |
專利國: | USA |
專利號碼: | 20170027877 |
顯示於類別: | 專利資料 |