標題: Nanocomposite, a Preparation Method Thereof and Method for Treating Cancer Using the Same
作者: Wei-Ting Huang
Yu-Chien Chiang
Dean-Mo Liu
公開日期: 4-十月-2018
摘要: A nanocomposite, a preparation method thereof and a method for treating cancer using the same are provided. The preparation method includes: mixing a first solution including an amphiphilic chitosan and a second solution including anti-cancer components, wherein the anti-cancer components includes gemcitabine, curcumin, the derivatives and combinations thereof; forming a nanoparticle encapsulating the anti-cancer component by a self-assembling process of the amphiphilic chitosan, and binding the nanoparticle with a targeting molecule having specificity to a cancer so as to obtain a nanocomposite. When dissolving the nanocomposite of the present invention after drying into water phase, the nanocomposite still has the same morphology and characteristic before it is dried, so it is convenient for storage and delivery. Additionally, the preferable ratio of gemcitabine and demethoxycurcumin will bring a synergistic effect on cancer therapy.
官方說明文件#: A61K047/36
C07K016/28
A61K039/395
A61K047/16
URI: http://hdl.handle.net/11536/151440
專利國: USA
專利號碼: 20180280517
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