標題: Fluorescent B-10 embedded nanodiamonds as B-10 delivery agent for boron neutron capture therapy
作者: Lin, Bo-Rong
Kunuku, Srinivasu
Chen, Tzung-Yuang
Chang, Yu-Jen
Liao, Li-Chuan
Chen, Chien-Hsu
Hsiao, Tung-Yuan
Yu, Hung-Kai
Niu, Huan
Lee, Chien-Ping
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
關鍵字: nanodiamonds;ion implantation;boron neutron capture therapy;boron delivery agent;fluorescence;IVIS
公開日期: 26-六月-2019
摘要: Boron neutron capture therapy is a potentially powerful anti-cancer treatment, the success of which depends heavily on the boron delivery agent. Enabling the real-time tracing of delivery agents as they move through the body is crucial to the further development of boron neutron capture therapy. In this study, we fabricate fluorescent B-10 embedded nanodiamonds using physical ion implantation in conjunction with a two-step annealing process. Fluorescent B-10 embedded nanodiamonds perform well in cell viability test. The red fluorescence of the B-10 embedded nanodiamonds allows their use in fluorescence microscopy and in vivo imaging systems, thereby making it possible to conduct tracking in real time. The proposed fluorescent B-10 embedded nanodiamonds, combining optical visibility and B-10 transport capability, might be a promising boron delivery agent suitable for a wide range of biomedical applications.
URI: http://dx.doi.org/10.1088/1361-6463/ab188c
http://hdl.handle.net/11536/151940
ISSN: 0022-3727
DOI: 10.1088/1361-6463/ab188c
期刊: JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume: 52
Issue: 26
起始頁: 0
結束頁: 0
顯示於類別:期刊論文