標題: | Fluorescent B-10 embedded nanodiamonds as B-10 delivery agent for boron neutron capture therapy |
作者: | Lin, Bo-Rong Kunuku, Srinivasu Chen, Tzung-Yuang Chang, Yu-Jen Liao, Li-Chuan Chen, Chien-Hsu Hsiao, Tung-Yuan Yu, Hung-Kai Niu, Huan Lee, Chien-Ping 電子工程學系及電子研究所 Department of Electronics Engineering and Institute of Electronics |
關鍵字: | nanodiamonds;ion implantation;boron neutron capture therapy;boron delivery agent;fluorescence;IVIS |
公開日期: | 26-六月-2019 |
摘要: | Boron neutron capture therapy is a potentially powerful anti-cancer treatment, the success of which depends heavily on the boron delivery agent. Enabling the real-time tracing of delivery agents as they move through the body is crucial to the further development of boron neutron capture therapy. In this study, we fabricate fluorescent B-10 embedded nanodiamonds using physical ion implantation in conjunction with a two-step annealing process. Fluorescent B-10 embedded nanodiamonds perform well in cell viability test. The red fluorescence of the B-10 embedded nanodiamonds allows their use in fluorescence microscopy and in vivo imaging systems, thereby making it possible to conduct tracking in real time. The proposed fluorescent B-10 embedded nanodiamonds, combining optical visibility and B-10 transport capability, might be a promising boron delivery agent suitable for a wide range of biomedical applications. |
URI: | http://dx.doi.org/10.1088/1361-6463/ab188c http://hdl.handle.net/11536/151940 |
ISSN: | 0022-3727 |
DOI: | 10.1088/1361-6463/ab188c |
期刊: | JOURNAL OF PHYSICS D-APPLIED PHYSICS |
Volume: | 52 |
Issue: | 26 |
起始頁: | 0 |
結束頁: | 0 |
顯示於類別: | 期刊論文 |