標題: Remote Magnetic Control of Autophagy in Mouse B-Lymphoma Cells with Iron Oxide Nanoparticles
作者: Lin, You-Rong
Chan, Chia-Hao
Lee, Hui-Ting
Cheng, Sheng-Jen
Yang, Jia-Wei
Chang, Shing-Jyh
Lin, Shien-Fong
Chen, Guan-Yu
交大名義發表
生物科技學系
National Chiao Tung University
Department of Biological Science and Technology
關鍵字: autophagy;magnetic field;iron oxide nanoparticle;proinflammatory cytokine
公開日期: 1-四月-2019
摘要: Autophagy is the spontaneous degradation of intracellular proteins and organelles in response to nutrient deprivation. The phagocytosis of iron oxide nanoparticles (IONPs) results in intracellular degradation that can be exploited for use in cancer treatment. Non-invasive magnetic control has emerged as an important technology, with breakthroughs achieved in areas such as magneto-thermal therapy and drug delivery. This study aimed to regulate autophagy in mouse B-lymphoma cells (A20) through the incorporation of IONPs-quantum dots (QDs). We hypothesized that with the application of an external magnetic field after phagocytosis of IONPs-QDs, autophagy of intracellular IONPs-QDs could be regulated in a non-invasive manner and subsequently modulate the regulation of inflammatory responses. The potential of this approach as a cancer treatment method was explored. The application of IONPs and an external magnetic force enabled the non-invasive regulation of cell autophagy and modulation of the self-regulatory function of cells. The combination of non-invasive magnetic fields and nanotechnology could provide a new approach to cancer treatment.
URI: http://dx.doi.org/10.3390/nano9040551
http://hdl.handle.net/11536/151984
ISSN: 2079-4991
DOI: 10.3390/nano9040551
期刊: NANOMATERIALS
Volume: 9
Issue: 4
起始頁: 0
結束頁: 0
顯示於類別:期刊論文