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dc.contributor.authorHung, Sheng-Cheen_US
dc.contributor.authorLee, Cheng-Chiaen_US
dc.contributor.authorChen, Hsin-Hungen_US
dc.contributor.authorChen, Chienen_US
dc.contributor.authorWu, Hsiu-Meien_US
dc.contributor.authorLin, Ching-Poen_US
dc.contributor.authorPeng, Syu-Jyunen_US
dc.date.accessioned2019-08-02T02:15:32Z-
dc.date.available2019-08-02T02:15:32Z-
dc.date.issued2019-06-01en_US
dc.identifier.issn0013-9580en_US
dc.identifier.urihttp://dx.doi.org/10.1111/epi.14933en_US
dc.identifier.urihttp://hdl.handle.net/11536/152221-
dc.description.abstractObjective To investigate whether interhemispheric functional connectivity (FC) recovers in the first year after total callosotomy. Methods Eight epilepsy patients undergoing total callosotomy were recruited. Resting-state functional magnetic resonance imaging was acquired before and after surgery. The precallosotomy and postcallosotomy interhemispheric and intrahemispheric FC was analyzed by using graph theory and voxel-mirrored homotopic connectivity (VMHC). The seizure outcome was scored using the Engel surgical outcome scale. Results After callosotomy (mean postoperative interval = 4 months), the network density, average node degree, characteristic path length, and global efficiency of the whole interhemispheric networks were significantly decreased, compared to those in the precallosotomy networks. However, postcallosotomy interhemispheric FC and homotopic VMHC were not significantly reduced in bilateral frontal and temporal lobes. The network density and average node degree of the intrahemispheric networks were significantly increased. The characteristic path length and global efficiency of intrahemispheric networks were unchanged. Significance The interhemispheric FC may be preserved or recover early within the first postoperative year after total callosotomy, particularly in the frontal and anterior temporal lobes.en_US
dc.language.isoen_USen_US
dc.subjectcorpus callosotomyen_US
dc.subjectgraph theoryen_US
dc.subjectinterhemispheric functional connectivityen_US
dc.subjectvoxel-mirrored homotopic connectivityen_US
dc.titleEarly recovery of interhemispheric functional connectivity after corpus callosotomyen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/epi.14933en_US
dc.identifier.journalEPILEPSIAen_US
dc.citation.volume60en_US
dc.citation.issue6en_US
dc.citation.spage1126en_US
dc.citation.epage1136en_US
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.department生醫電子轉譯研究中心zh_TW
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.contributor.departmentBiomedical Electronics Translational Research Centeren_US
dc.identifier.wosnumberWOS:000472983800013en_US
dc.citation.woscount0en_US
Appears in Collections:Articles