標題: Intervening Nidal Brain Parenchyma and Risk of Radiation-Induced Changes After Radiosurgery for Brain Arteriovenous Malformation: A Study Using an Unsupervised Machine Learning Algorithm
作者: Lee, Cheng-Chia
Yang, Huai-Che
Lin, Chung-Jung
Chen, Ching-Jen
Wu, Hsiu-Mei
Shiau, Cheng-Ying
Guo, Wan-Yuo
Pan, David Hung-Chi
Liu, Kang-Du
Chung, Wen-Yuh
Peng, Syu-Jyun
電子工程學系及電子研究所
生醫電子轉譯研究中心
Department of Electronics Engineering and Institute of Electronics
Biomedical Electronics Translational Research Center
關鍵字: Adverse radiation effects;Arteriovenous malformation;Fuzzy c-means;Gamma knife radiosurgery;Image analysis;Radiation-induced changes;Stereotactic radiosurgery
公開日期: 1-五月-2019
摘要: OBJECTIVE: To assess the sensitivity and specificity of arteriovenous malformation (AVM) nidal component identification and quantification using an unsupervised machine learning algorithm and to evaluate the association between intervening nidal brain parenchyma and radiationinduced changes (RICs) after stereotactic radiosurgery. METHODS: Fully automated segmentation via unsupervised classification with fuzzy c-means clustering was used to analyze the AVM nidus on T2-weighted magnetic resonance imaging studies. The proportions of vasculature, brain parenchyma, and cerebrospinal fluid were quantified. These were compared with the results from manual segmentation. The association between the brain parenchyma component and RIC development was assessed. RESULTS: The proposed algorithm was applied to 39 unruptured AVMs in 39 patients (17 female and 22 male patients), with a median age of 27 years. The median proportion of the constituents was as follows: vasculature, 31.3%; brain parenchyma, 48.4%; and cerebrospinal fluid, 16.8%. RICs were identified in 17 of the 39 patients (43.6%). Compared with manual segmentation, the automated algorithm was able to achieve a Dice similarity index of 79.5% (sensitivity, 73.5%; specificity, 85.5%). RICs were associated with a greater proportion of intervening nidal brain parenchyma (52.0% vs. 45.3%; P = 0.015). Obliteration was not associated with greater proportions of nidal vasculature (36.0% vs. 31.2%; P = 0.152). CONCLUSIONS: The automated segmentation algorithm was able to achieve classification of the AVM nidus components with relative accuracy. Greater proportions of intervening nidal brain parenchyma were associated with RICs.
URI: http://dx.doi.org/10.1016/j.wneu.2018.12.220
http://hdl.handle.net/11536/152308
ISSN: 1878-8750
DOI: 10.1016/j.wneu.2018.12.220
期刊: WORLD NEUROSURGERY
Volume: 125
起始頁: 0
結束頁: 0
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