標題: Simulation of Axon Activation by Electrical Stimulation-Applying Alternating-Direction-Implicit Finite-Difference Time-Domain Method
作者: Choi, Charles T. M.
Sun, Shu-Hai
分子醫學與生物工程研究所
資訊工程學系
電機工程學系
Institute of Molecular Medicine and Bioengineering
Department of Computer Science
Department of Electrical and Computer Engineering
關鍵字: Alternating-direction-implicit finite-difference time-domain (ADI-FDTD);axon stimulation;cable model;Hodgkin-Huxley (HH) model
公開日期: 1-Feb-2012
摘要: In a typical approach to model electrical stimulation of an axon, a cable model equivalent to an axon was placed in a simple homogeneous medium. An electrode was used to induce an excitation to stimulate the cable model, and then the transmembrane potentials and the ionic currents in the cable model in temporal domain were observed. Unfortunately, this simulation approach is not realistic since inhomogeneous tissues near the axon is not considered. In this paper, the alternating-direction-implicit finite-difference time-domain (ADI-FDTD) method is coupled with the equivalent model of a membrane (the Hodgkin-Huxley model), and a novel simulation scheme is developed to predict axon activation. By testing axon activation with current excitation, the simulation results show the new method is useful for simulating axon activation.
URI: http://dx.doi.org/10.1109/TMAG.2011.2175377
http://hdl.handle.net/11536/15231
ISSN: 0018-9464
DOI: 10.1109/TMAG.2011.2175377
期刊: IEEE TRANSACTIONS ON MAGNETICS
Volume: 48
Issue: 2
起始頁: 639
結束頁: 642
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