標題: | Enterotype-based Analysis of Gut Microbiota along the Conventional Adenoma-Carcinoma Colorectal Cancer Pathway |
作者: | Yang, Tzu-Wei Lee, Wei-Hsiang Tu, Siang-Jyun Huang, Wei-Chih Chen, Hui-Mei Sun, Ting-Hsuan Tsai, Ming-Chang Wang, Chi-Chih Chen, Hsuan-Yi Huang, Chi-Chou Shiu, Bei-Hao Yang, Tzu-Ling Huang, Hsin-Tzu Chou, Yu-Pao Chou, Chih-Hung Huang, Ya-Rong Sun, Yi-Run Liang, Chao Lin, Feng-Mao Ho, Shinn-Ying Chen, Wen-Liang Yang, Shun-Fa Ueng, Kwo-Chang Huang, Hsien-Da Huang, Chien-Ning Jong, Yuh-Jyh Lin, Chun-Che 交大名義發表 生物科技學院 National Chiao Tung University College of Biological Science and Technology |
公開日期: | 29-Jul-2019 |
摘要: | The dysbiosis of human gut microbiota is strongly associated with the development of colorectal cancer (CRC). The dysbiotic features of the transition from advanced polyp to early-stage CRC are largely unknown. We performed a 16S rRNA gene sequencing and enterotype-based gut microbiota analysis study. In addition to Bacteroides-and Prevotella-dominated enterotypes, we identified an Escherichia-dominated enterotype. We found that the dysbiotic features of CRC were dissimilar in overall samples and especially Escherichia-dominated enterotype. Besides a higher abundance of Fusobacterium, Enterococcus, and Aeromonas in all CRC faecal microbiota, we found that the most notable characteristic of CRC faecal microbiota was a decreased abundance of potential beneficial butyrate-producing bacteria. Notably, Oscillospira was depleted in the transition from advanced adenoma to stage 0 CRC, whereas Haemophilus was depleted in the transition from stage 0 to early-stage CRC. We further identified 7 different CAGs by analysing bacterial clusters. The abundance of microbiota in cluster 3 significantly increased in the CRC group, whereas that of cluster 5 decreased. The abundance of both cluster 5 and cluster 7 decreased in the Escherichia-dominated enterotype of the CRC group. We present the first enterotype-based faecal microbiota analysis. The gut microbiota of colorectal neoplasms can be influenced by its enterotype. |
URI: | http://dx.doi.org/10.1038/s41598-019-45588-z http://hdl.handle.net/11536/152678 |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-019-45588-z |
期刊: | SCIENTIFIC REPORTS |
Volume: | 9 |
起始頁: | 0 |
結束頁: | 0 |
Appears in Collections: | Articles |