標題: The Impact of Antidepressants on the Risk of Developing Obstructive Sleep Apnea in Posttraumatic Stress Disorder: A Nationwide Cohort Study in Taiwan
作者: Lin, Ching-En
Chung, Chi-Hsiang
Chen, Li-Fen
Chien, Wu-Chien
Chou, Po-Han
交大名義發表
生物科技學系
National Chiao Tung University
Department of Biological Science and Technology
關鍵字: antidepressants;obstructive sleep apnea;posttraumatic stress disorder;sleep-disordered breathing
公開日期: 15-Sep-2019
摘要: Study Objectives: The association between posttraumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) has been reported inconsistently, and the association between antidepressant use and the risk of developing OSA in patients with PTSD has not been previously studied. Therefore, we used the Longitudinal National Health Insurance Database (LHID) to investigate the impact of PTSD and antidepressant use on the risk of OSA development. Methods: Identified from the LHID, 2,316 individuals aged >= 18 years with PTSD, but with no history of OSA, and 23,160 control individuals matched forage, sex, obesity and index date were enrolled between 2000 and 2015 and followed up until the end of 2015 to identify the development of OSA. A two-tailed Bonferroni-corrected P < .00038 (.05/13) was considered statistically significant as we examined 13 antidepressants. Results: Individuals with PTSD had increased risk of developing OSA (adjusted hazard ratio 4.672, 95% confidence interval 2.246-9.787, P < .001) after adjusting for demographic data, medical comorbidities, and medication. Treatment with antidepressants was not significantly associated with an increased risk of developing OSA compared to no antidepressant treatment. Conclusions: Asian patients with PTSD had increased risk of developing OSA, and treatment with antidepressants did not play a key role in increasing the risk of OSA development. Further studies are required to investigate the underlying mechanisms of PTSD and the roles of antidepressants on the risk of developing OSA.
URI: http://dx.doi.org/10.5664/jcsm.7910
http://hdl.handle.net/11536/152777
ISSN: 1550-9389
DOI: 10.5664/jcsm.7910
期刊: JOURNAL OF CLINICAL SLEEP MEDICINE
Volume: 15
Issue: 9
起始頁: 1233
結束頁: 1241
Appears in Collections:Articles