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dc.contributor.authorJang, Tyng-Yuanen_US
dc.contributor.authorHuang, Ching-, Ien_US
dc.contributor.authorYeh, Ming-Lunen_US
dc.contributor.authorLiang, Po-Chengen_US
dc.contributor.authorTsai, Pei-Chienen_US
dc.contributor.authorLin, Yi-Hungen_US
dc.contributor.authorHsieh, Ming-Yenen_US
dc.contributor.authorHou, Nai-Jenen_US
dc.contributor.authorLin, Zu-Yauen_US
dc.contributor.authorChen, Shinn-Cherngen_US
dc.contributor.authorHuang, Jee-Fuen_US
dc.contributor.authorDai, Chia-Yenen_US
dc.contributor.authorHuang, Chung-Fengen_US
dc.contributor.authorChuang, Wan-Longen_US
dc.contributor.authorYu, Ming-Lungen_US
dc.date.accessioned2019-12-13T01:09:55Z-
dc.date.available2019-12-13T01:09:55Z-
dc.date.issued1970-01-01en_US
dc.identifier.issn0815-9319en_US
dc.identifier.urihttp://dx.doi.org/10.1111/jgh.14835en_US
dc.identifier.urihttp://hdl.handle.net/11536/153017-
dc.description.abstractBackground and Aim Hepatitis C virus eradication via the use of antivirals ameliorates metabolic profiles. The changes in serum uric acid (SUA) levels in chronic hepatitis C patients who receive antivirals are not well understood. We aimed to address this issue by comparing the SUA changes before and after the achievement of a sustained virological response (which is defined as hepatitis C virus RNA seronegativity at 12 weeks after the end of treatment). Methods Two hundred and thirteen sustained virological response patients who were treated by directly acting antivirals were consecutively enrolled. Pretreatment and post-treatment SUA levels were compared. Hyperuricemia was defined as a uric acid level > 7.0 mg/dL in men and > 6.0 mg/dL in women. Results The SUA levels significantly decreased after treatment, as compared to the pretreatment levels (5.6 +/- 1.5 vs 6.0 +/- 1.7 mg/dL, respectively; P < 0.001). The proportion of hyperuricemia incidences significantly decreased after treatment (25.8% vs 35.7%, respectively; P = 0.001). The improvement was only observed in patients with a fibrosis-4 index (FIB-4) < 6.5 (25.7% vs 37.1%, P = 0.001) but not in those patients with a FIB-4 >= 6.5 (26.3% vs 28.9%, P = 1.00). A multivariate analysis revealed that the factor that was associated with significantly decreased SUA levels was FIB-4 < 6.5 (odds ratio [OR]/95% confidence interval [CI]: 3.22/1.04-9.95, P = 0.04) and estimated glomerular filtration rate < 60 mL/min/1.73 m(2) (OR/CI: 4.34/1.94-9.73, P < 0.001). There existed a trend of a higher proportion of patients with significant SUA improvement along with the decrement of FIB-4 (29.7%, 25%, and 10.5% in patients with FIB-4 < 3.25, 3.25-6.5, and > 6.5, respectively; trend P = 0.03). Conclusions SUA levels were significantly decreased in chronic hepatitis C patients after viral eradication. The improvement was particularly enhanced in patients with mild liver disease.en_US
dc.language.isoen_USen_US
dc.subjectCHCen_US
dc.subjectDAAen_US
dc.subjectFIB-4en_US
dc.subjecthyperuricemiaen_US
dc.subjectliver fibrosisen_US
dc.titleImprovement of hyperuricemia in chronic hepatitis C patients receiving directly acting antiviral agentsen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/jgh.14835en_US
dc.identifier.journalJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGYen_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000490295800001en_US
dc.citation.woscount0en_US
Appears in Collections:Articles