標題: Improvement of hyperuricemia in chronic hepatitis C patients receiving directly acting antiviral agents
作者: Jang, Tyng-Yuan
Huang, Ching-, I
Yeh, Ming-Lun
Liang, Po-Cheng
Tsai, Pei-Chien
Lin, Yi-Hung
Hsieh, Ming-Yen
Hou, Nai-Jen
Lin, Zu-Yau
Chen, Shinn-Cherng
Huang, Jee-Fu
Dai, Chia-Yen
Huang, Chung-Feng
Chuang, Wan-Long
Yu, Ming-Lung
交大名義發表
生物科技學系
National Chiao Tung University
Department of Biological Science and Technology
關鍵字: CHC;DAA;FIB-4;hyperuricemia;liver fibrosis
公開日期: 1-Jan-1970
摘要: Background and Aim Hepatitis C virus eradication via the use of antivirals ameliorates metabolic profiles. The changes in serum uric acid (SUA) levels in chronic hepatitis C patients who receive antivirals are not well understood. We aimed to address this issue by comparing the SUA changes before and after the achievement of a sustained virological response (which is defined as hepatitis C virus RNA seronegativity at 12 weeks after the end of treatment). Methods Two hundred and thirteen sustained virological response patients who were treated by directly acting antivirals were consecutively enrolled. Pretreatment and post-treatment SUA levels were compared. Hyperuricemia was defined as a uric acid level > 7.0 mg/dL in men and > 6.0 mg/dL in women. Results The SUA levels significantly decreased after treatment, as compared to the pretreatment levels (5.6 +/- 1.5 vs 6.0 +/- 1.7 mg/dL, respectively; P < 0.001). The proportion of hyperuricemia incidences significantly decreased after treatment (25.8% vs 35.7%, respectively; P = 0.001). The improvement was only observed in patients with a fibrosis-4 index (FIB-4) < 6.5 (25.7% vs 37.1%, P = 0.001) but not in those patients with a FIB-4 >= 6.5 (26.3% vs 28.9%, P = 1.00). A multivariate analysis revealed that the factor that was associated with significantly decreased SUA levels was FIB-4 < 6.5 (odds ratio [OR]/95% confidence interval [CI]: 3.22/1.04-9.95, P = 0.04) and estimated glomerular filtration rate < 60 mL/min/1.73 m(2) (OR/CI: 4.34/1.94-9.73, P < 0.001). There existed a trend of a higher proportion of patients with significant SUA improvement along with the decrement of FIB-4 (29.7%, 25%, and 10.5% in patients with FIB-4 < 3.25, 3.25-6.5, and > 6.5, respectively; trend P = 0.03). Conclusions SUA levels were significantly decreased in chronic hepatitis C patients after viral eradication. The improvement was particularly enhanced in patients with mild liver disease.
URI: http://dx.doi.org/10.1111/jgh.14835
http://hdl.handle.net/11536/153017
ISSN: 0815-9319
DOI: 10.1111/jgh.14835
期刊: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
起始頁: 0
結束頁: 0
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