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dc.contributor.authorWang, Hsin-Huien_US
dc.contributor.authorHuang, Chung-Haoen_US
dc.contributor.authorKuo, Mei-Chuanen_US
dc.contributor.authorLin, Shang-Yien_US
dc.contributor.authorHsu, Chin-Hueien_US
dc.contributor.authorLee, Chun-Yuanen_US
dc.contributor.authorChiu, Yi-Wenen_US
dc.contributor.authorChen, Yen-Hsuen_US
dc.contributor.authorLu, Po-Liangen_US
dc.date.accessioned2019-12-13T01:10:00Z-
dc.date.available2019-12-13T01:10:00Z-
dc.date.issued2019-10-01en_US
dc.identifier.issn1684-1182en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jmii.2018.10.013en_US
dc.identifier.urihttp://hdl.handle.net/11536/153076-
dc.description.abstractBackground: Peritoneal dialysis (PD)-related infection is a serious complication of patients with PD. Refractory peritonitis may lead to failure of PD, shift to hemodialysis (HD) or death. Besides, microbiologic resistance increased worldwide that might impact the treatment choice for such infections. Investigating the causative pathogens and risk factors of PD-related infections in Taiwan was warranted. Methods: This is a retrospective study involving patients with PD from 2007 to 2016 in a southern Taiwan hospital. Patient characteristics, microbiological data, outcomes, and factors associated with refractory peritonitis were analyzed. Results: There were 190 episodes of PD-related peritonitis in 110 patients from this cohort. Gram-positive organisms were the leading cause of PD-related peritonitis, but gram-negative organisms, esp. Pseudomonas aeruginosa, were predominant for exit site infection and tunnel infection. The incidence of peritonitis was 0.25 episode per patient-year (1 episode per 47.69 months). The refractory rate was 14.2% (27/190). Methicillin resistance was noted in 2 (13.3%) of 15 Staphylococcus aureus isolates. Of 114 isolates, 72.8% (83) were susceptible to either cefazolin or gentamicin. Staphylococcus spp. and Escherichia coli infections were significantly associated with refractory peritonitis. Baseline hyponatremia (<130 mmol/L) was independently associated with refractory peritonitis. Conclusion: Gram-positive organisms remained major cause of PD-related peritonitis. About three quarters of causative pathogens were susceptible to the recommended empirical treatment for PD-related peritonitis. Baseline hyponatremia (<130 mmol/L) was independently associated with refractory peritonitis. Staphylococcus spp. and E. coli infections had important roles for refractory peritonitis. Copyright (C) 2019, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.en_US
dc.language.isoen_USen_US
dc.subjectMicrobiological trenden_US
dc.subjectPeritoneal dialysisen_US
dc.subjectPeritonitisen_US
dc.subjectRefractoryen_US
dc.titleMicrobiology of peritoneal dialysis-related infection and factors of refractory peritoneal dialysis related peritonitis: A ten-year single-center study in Taiwanen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jmii.2018.10.013en_US
dc.identifier.journalJOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTIONen_US
dc.citation.volume52en_US
dc.citation.issue5en_US
dc.citation.spage752en_US
dc.citation.epage759en_US
dc.contributor.department生醫工程研究所zh_TW
dc.contributor.departmentInstitute of Biomedical Engineeringen_US
dc.identifier.wosnumberWOS:000487963100010en_US
dc.citation.woscount0en_US
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