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dc.contributor.authorChang, Yu-Weien_US
dc.contributor.authorHuang, Wan-Chunen_US
dc.contributor.authorLin, Chun-Yuen_US
dc.contributor.authorWang, Wen-Hungen_US
dc.contributor.authorHung, Ling-Chienen_US
dc.contributor.authorChen, Yen-Hsuen_US
dc.date.accessioned2020-02-02T23:54:38Z-
dc.date.available2020-02-02T23:54:38Z-
dc.date.issued2019-11-01en_US
dc.identifier.urihttp://dx.doi.org/10.3390/ijms20225790en_US
dc.identifier.urihttp://hdl.handle.net/11536/153588-
dc.description.abstractThe emergence of methicillin-resistant Staphylococcus aureus (MRSA) has become a critical global concern. Identifying new candidates of anti-S. aureus agents is urgently required because the therapeutic strategies for infected patients are limited currently. Therefore, the present study investigated whether Tellimagrandin II (TGII), a pure compound extracted from the shells of Trapa bispinosa, exhibits antibacterial effects against MRSA. We first showed that TGII exerted potent inhibitory activity against MRSA with a minimum inhibitory concentration of 128 mu g/mL. The obtained fractional inhibitory concentration suggested that TGII could alone exert antistaphylococcal activity, and TGII combined with low doses of antibiotics displayed synergistic effects against MRSA. Moreover, we found that TGII exerted bactericidal activity by reducing the expression of mecA followed by the negative regulation of the penicillin-binding protein 2a (PBP2a) of MRSA. Transmission electron microscopy (TEM) images further confirmed that TGII destroyed the integrity of the cell wall of MRSA and caused the loss of cytoplasm content. In conclusion, we evidenced the antibacterial effects of TGII against MRSA, which enables the effective dose of current antibiotics to be reduced and the predicament of drug-resistant S. aureus isolates to be overcome.en_US
dc.language.isoen_USen_US
dc.subjectMRSAen_US
dc.subjectTGIIen_US
dc.subjectsynergistic effecten_US
dc.subjectcombination therapyen_US
dc.titleTellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureusen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms20225790en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESen_US
dc.citation.volume20en_US
dc.citation.issue22en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000502786800272en_US
dc.citation.woscount0en_US
Appears in Collections:Articles