標題: | Longitudinal and quantitative assessment platform for concurrent analysis of anti-tumor efficacy and cardiotoxicity of nano-formulated medication in vivo |
作者: | Tu, Wei-Ming Huang, Xin-Chun Chen, Yen-Ling Luo, Yun-Ling Liau, Ian Hsu, Hsin-Yun 交大名義發表 應用化學系 應用化學系分子科學碩博班 National Chiao Tung University Department of Applied Chemistry Institute of Molecular science |
關鍵字: | Nanoformulated medication;Chemotherapeutics;Cardiotoxicity;Zebrafish tumor model;Pseudodynamic 3D imaging |
公開日期: | 25-一月-2020 |
摘要: | Increasing nanomedicinal approaches have been developed to effectively inhibit tumor growth; however, critical questions such as whether a nanomedicinal approach can mitigate latent side effects are barely addressed. To this end, we established a zebrafish xenograft tumor model, combining pseudodynamic three-dimensional cardiac imaging and image analysis to enable simultaneous and quantitative determination of the change of tumor volume and cardiac function of zebrafish upon specific nanoformulation treatment. Doxorubicin (DOX), a well-known chemotherapeutic agent with cardiotoxicity, and a recently developed DOX-loaded nanocomposite were employed as two model drugs to demonstrate the effectiveness to utilize the proposed evaluation platform for rapid validation. The nanoformulation significantly mitigated DOX-associated cardiotoxicity, while retaining the efficacy of DOX in inhibiting tumor growth compared to administration of carrier-free DOX at the same dose. We anticipate that this platform possesses the potential as an efficient assessment system for nanoformulated cancer therapeutics with suspected toxicity and side effects to vital organs such as the heart. (C) 2019 Elsevier B.V. All rights reserved. |
URI: | http://dx.doi.org/10.1016/j.aca.2019.10.019 http://hdl.handle.net/11536/153601 |
ISSN: | 0003-2670 |
DOI: | 10.1016/j.aca.2019.10.019 |
期刊: | ANALYTICA CHIMICA ACTA |
Volume: | 1095 |
起始頁: | 129 |
結束頁: | 137 |
顯示於類別: | 期刊論文 |