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dc.contributor.authorChen, Jung-Chihen_US
dc.contributor.authorChang, Hsin-Yunen_US
dc.contributor.authorChen, Jiun-Jungen_US
dc.contributor.authorChen, Gin-Shinen_US
dc.date.accessioned2020-02-02T23:54:40Z-
dc.date.available2020-02-02T23:54:40Z-
dc.date.issued2019-11-15en_US
dc.identifier.issn1530-437Xen_US
dc.identifier.urihttp://dx.doi.org/10.1109/JSEN.2019.2934741en_US
dc.identifier.urihttp://hdl.handle.net/11536/153612-
dc.description.abstractAcoustic cavitation plays a key role in blood-brain-barrier opening. Stable cavitation is required for safely transient barrier disruption when inertial cavitation may cause potentially undesirable damage to brain. To ensure the safety, an appropriate passive cavitation detector is needed to monitor cavitation activity during focused ultrasound treatment. The purpose of this study was to develop a passive cavitation detector with high sensitivity at the specific frequency used in blood-brain-barrier opening. The detector was designed with the assistance of pulse-echo response simulations, using the software PiezoCAD. The active transducer of the detector was constructed of two matching layers, a PZT-5A ceramic disk and the titanium backing. The detector was characterized via the pulse-echo measurements and a commercial hydrophone was used to determine the sensitivity of the developed detector. Cavitation experiments were also performed to validate the detector. The experimental results showed that the detector had the center frequency of 1.16 MHz with the bandwidth of 44.8% and its sensitivity was 2.87 V / MPa at 1.0 MHz. In cavitation experiments, 2-MHz focused ultrasound with the focal intensity of 58 W/cm(2) and 1461 W/cm(2) induced stable cavitation and inertial cavitation in free field, separately. The spectra of the ultrasound signals detected by the detector indicated the occurrence of peak voltages at the subharmonic frequency of 1 MHz and the increase in the level of wideband signals, reflecting stable cavitation and inertial cavitation, respectively. Based on the design guideline of this study, the passive cavitation detector can be developed dedicated for blood-brain-barrier opening.en_US
dc.language.isoen_USen_US
dc.subjectBlood-brain barrieren_US
dc.subjectfocused ultrasounden_US
dc.subjectcavitationen_US
dc.subjectpassive cavitation detectoren_US
dc.subjectPZT-5Aen_US
dc.titleA Piezoceramic Sensor for Detection of Focused Ultrasound-Induced Cavitationen_US
dc.typeArticleen_US
dc.identifier.doi10.1109/JSEN.2019.2934741en_US
dc.identifier.journalIEEE SENSORS JOURNALen_US
dc.citation.volume19en_US
dc.citation.issue22en_US
dc.citation.spage10379en_US
dc.citation.epage10385en_US
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000503399200025en_US
dc.citation.woscount0en_US
Appears in Collections:Articles