標題: | Magnolol-Loaded Core-Shell Hydrogel Nanoparticles: Drug Release, Intracellular Uptake, and Controlled Cytotoxicity for the Inhibition of Migration of Vascular Smooth Muscle Cells |
作者: | Wang, Yen-Jen Chien, Yin-Chih Wu, Chieh-Hsi Liu, Dean-Mo 材料科學與工程學系 Department of Materials Science and Engineering |
關鍵字: | core-shell hydrogel nanoparticle;magnolol-CHC nanoparticle;cell migration inhibition;cell uptake;magnolol;intracellular delivery |
公開日期: | 1-十一月-2011 |
摘要: | Encapsulation and release behavior of a water-insoluble drug, magnolol, using a core shell polysaccharide-based nanoparticle, manipulating the cellular internalization and controlled cytotoidc effect of magnolol-loaded nanoparticles over the A10 vascular smooth muscle cells (VSMCs) was reported. A magnolol-polyvinylpyrrolidone (PVP) core phase was prepared, followed encapsulating by an amphiphilic carboxymethyl-hexanoyi chitosan (CHC) shell to form a magnolol-loaded core-shell hydrogel nanoparticles (termed magnolol-CHC nanoparticles). The resulting magnolol-CHC nanopartides were employed for evaluation of drug release and controlled cytotoxic inhibition of VSMCs migration in vitro. A sustained release of the magnolol from the nanoparticles was determined. The magnolol-CHC nanoparticles exhibited outstanding cellular uptake efficiency, and under a cytotoxic evaluation, an increased antiproliferative effect and effective inhibition of VSMC migration as a result of efficient intracellular delivery of the encapsulated magnolol in comparison to free magnolol was achieved. We then envision a potential intracellular medication strategy with improved biological and therapeutic efficacy using the magnolol-CHC nanoparticles illustrated in this work. |
URI: | http://dx.doi.org/10.1021/mp200257y http://hdl.handle.net/11536/15377 |
ISSN: | 1543-8384 |
DOI: | 10.1021/mp200257y |
期刊: | MOLECULAR PHARMACEUTICS |
Volume: | 8 |
Issue: | 6 |
起始頁: | 2339 |
結束頁: | 2349 |
顯示於類別: | 期刊論文 |