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dc.contributor.authorHuang, Chih-Maoen_US
dc.contributor.authorFan, Yang-Tengen_US
dc.contributor.authorLee, Shwu-Huaen_US
dc.contributor.authorLiu, Ho-Lingen_US
dc.contributor.authorChen, Yao-Liangen_US
dc.contributor.authorLin, Cheminen_US
dc.contributor.authorLee, Tatia M. C.en_US
dc.date.accessioned2020-05-05T00:01:31Z-
dc.date.available2020-05-05T00:01:31Z-
dc.date.issued2019-08-01en_US
dc.identifier.issn1749-5016en_US
dc.identifier.urihttp://dx.doi.org/10.1093/scan/nsz054en_US
dc.identifier.urihttp://hdl.handle.net/11536/153953-
dc.description.abstractLate-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain.en_US
dc.language.isoen_USen_US
dc.subjectcognitive reserveen_US
dc.subjectemotional regulationen_US
dc.subjectfMRIen_US
dc.subjectdepressionen_US
dc.subjectmediationen_US
dc.subjectagingen_US
dc.titleCognitive reserve-mediated neural modulation of emotional control and regulation in people with late-life depressionen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/scan/nsz054en_US
dc.identifier.journalSOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCEen_US
dc.citation.volume14en_US
dc.citation.issue8en_US
dc.citation.spage849en_US
dc.citation.epage860en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.department生物科技學院zh_TW
dc.contributor.departmentNational Chiao Tung Universityen_US
dc.contributor.departmentCollege of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000517160400005en_US
dc.citation.woscount0en_US
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