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dc.contributor.authorChen, Cheng Hsuen_US
dc.contributor.authorChang, Chih-Yuen_US
dc.contributor.authorYang, Mei-Chuehen_US
dc.contributor.authorWu, Jr-Hauen_US
dc.contributor.authorLiao, Ching-Huien_US
dc.contributor.authorSu, Chih-Peien_US
dc.contributor.authorChen, Yu-Chihen_US
dc.contributor.authorHo, Shinn-Yingen_US
dc.contributor.authorHuang, Cheng-Chiehen_US
dc.contributor.authorLee, Tsung-Hanen_US
dc.contributor.authorChen, Wen-Liangen_US
dc.contributor.authorChou, Chu-Chungen_US
dc.contributor.authorLin, Yan-Renen_US
dc.date.accessioned2020-05-05T00:02:26Z-
dc.date.available2020-05-05T00:02:26Z-
dc.date.issued2019-12-16en_US
dc.identifier.issn2090-2840en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2019/6218389en_US
dc.identifier.urihttp://hdl.handle.net/11536/154240-
dc.description.abstractBackground. Since out-of-hospital cardiac arrest- (OHCA-) related dysfunction (ischemic/reperfusion injury and inflammatory response) might result in long-term impairment, we suspect that new-onset heart failure might be common in long-term survivors. However, these relationships had not been well addressed, and we aimed to analyze the impact of emergency interventions and patient characteristics on the risk of new-onset heart failure in patients with nontraumatic OHCA. Methods. The Taiwanese government healthcare database contains data for 49,101 nontraumatic OHCA adult patients from 2011-2012, which were analyzed in this study. Nontraumatic OHCA patients who survived to the intensive care unit (ICU) were included as the study group (n = 7,321). Matched patients (n = 21,963) were recruited as a comparison group. Patients with any history of heart failure or cardiac arrest were not included in either group. All patients were followed-up for 6 months for the identification of new-onset heart failure. Adjustments were made for demographics, age, emergency interventions, and comorbidities as potential risk factors. Results. In all, 3.84% (n = 281) of OHCA patients suffered new-onset heart failure, while only 1.24% (n = 272) of matched patients in the comparison group suffered new-onset heart failure. Strong risk factors for heart failure were age (60-75 years, HR: 11.4; 95% CI: 9-14.4), medical history (myocardial infarction, HR: 2.47; 95% CI: 2.05-2.98 and cardiomyopathy, HR: 2.94; 95% CI: 1.45-5.94), and comorbidities during hospitalization (ischemic heart disease, HR: 4.5; 95% CI: 3.46-5.86). Only extracorporeal membrane oxygenation (ECMO) decreased the risk of heart failure. Most (53.6%) heart failure events occurred within 60 days after OHCA. Conclusion. An age from 61 to 75 years, a history of myocardial infarction or cardiomyopathy, and ischemic heart disease or infection as comorbidities occurring during hospitalization were strong risk factors for new-onset heart failure in OHCA patients. However, ECMO could decrease this risk. More importantly, most heart failure events occurred within 60 days after OHCA.en_US
dc.language.isoen_USen_US
dc.titleThe Impact of Emergency Interventions and Patient Characteristics on the Risk of Heart Failure in Patients with Nontraumatic OHCAen_US
dc.typeArticleen_US
dc.identifier.doi10.1155/2019/6218389en_US
dc.identifier.journalEMERGENCY MEDICINE INTERNATIONALen_US
dc.citation.volume2019en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000522250500001en_US
dc.citation.woscount0en_US
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