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dc.contributor.authorChang, Yu-Hsuanen_US
dc.contributor.authorPeng, Wan-Lingen_US
dc.contributor.authorChen, I-Chiaen_US
dc.contributor.authorHsu, Hsin-Yunen_US
dc.contributor.authorWu, Yen-Kuen_US
dc.date.accessioned2020-07-01T05:21:15Z-
dc.date.available2020-07-01T05:21:15Z-
dc.date.issued2020-04-30en_US
dc.identifier.issn1359-7345en_US
dc.identifier.urihttp://dx.doi.org/10.1039/d0cc00435aen_US
dc.identifier.urihttp://hdl.handle.net/11536/154321-
dc.description.abstractA method for the catalytic alpha-arylation of indolin-3-ones was developed. The catalytic system comprising Pd(dba)(2) and PAd(3) was found to be optimal for the transformation. The protocol features broad functional group compatibility in that a range of arylated indoxyl derivatives bearing a fully substituted carbon center was synthesized with high efficiency. A preliminary bioassay study revealed that the selected indole-substituted indolin-3-ones exhibit favorable cytotoxic activities against HCT-116 cancer cell line.en_US
dc.language.isoen_USen_US
dc.titlePalladium-catalyzed alpha-arylation of indolin-3-onesen_US
dc.typeArticleen_US
dc.identifier.doi10.1039/d0cc00435aen_US
dc.identifier.journalCHEMICAL COMMUNICATIONSen_US
dc.citation.volume56en_US
dc.citation.issue34en_US
dc.citation.spage4660en_US
dc.citation.epage4663en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000530725500003en_US
dc.citation.woscount0en_US
Appears in Collections:Articles


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