Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, Chang-Chiang | en_US |
dc.contributor.author | Hsieh, Ju-Chun | en_US |
dc.contributor.author | Chao, Cheng-Han | en_US |
dc.contributor.author | Yang, Wei-Shun | en_US |
dc.contributor.author | Cheng, Hui-Teng | en_US |
dc.contributor.author | Chan, Chieh-Kai | en_US |
dc.contributor.author | Lu, Chia-Jung | en_US |
dc.contributor.author | Meng, Hsin-Fei | en_US |
dc.contributor.author | Zan, Hsiao-Wen | en_US |
dc.date.accessioned | 2020-07-01T05:21:15Z | - |
dc.date.available | 2020-07-01T05:21:15Z | - |
dc.date.issued | 2020-07-01 | en_US |
dc.identifier.issn | 1752-7155 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1088/1752-7163/ab728b | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/154332 | - |
dc.description.abstract | Previous studies have shown that breath ammonia (breath-NH3) concentration is associated with blood urea nitrogen (BUN) levels. However, interindividual variations in breath-NH3 concentrations were observed. Thus, the present study aimed to assess the effect of oral cavity conditions on breath-NH3 concentration and to validate whether the measurement of breath-NH3 concentration is feasible in clinical settings. A total of 125 individuals, including patients with stage 3 to 5 chronic kidney disease (CKD3-5), those on dialysis, and healthy participants, were recruited. A nanostructured sensor was used to detect breath-NH3 concentrations. Pre- and post-gargling as well as pre- and post-hemodialysis (HD) breath-NH3, salivary pH, and salivary urea levels were measured. Breath-NH3, salivary urea, salivary pH, and BUN levels were positively correlated to each other. Breath-NH3 concentrations were associated with BUN levels (r = 0.43, p < 0.001) and were significantly higher in CKD3-5 (p < 0.005) and dialysis patients (p < 0.001) than in healthy participants. Higher correlation coefficients were noted between breath-NH3 concentrations and BUN levels during follow-up (r = 0.59-0.94, p < 0.05). When the cutoff value of breath-NH3 was set at 523.65 ppb, its sensitivity and specificity in predicting CKD (BUN level >24 mg dl(-1)) were 87.6% and 80.9%, respectively. Breath-NH3 concentrations decreased after HD (p < 0.001) and immediately after gargling (p < 0.01). Breath-NH3 concentration, which was affected by gargling, was correlated to BUN level. The measurement of breath-NH3 concentration using the nanostructured device may be used as a tool for CKD detection and personalized point-of-care for CKD and dialysis patients. The current study had a small sample size. Thus, further studies with a larger cohort must be conducted to validate the effect of oral factors on breath-NH3 concentration and to validate the benefit of breath-NH3 measurement. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | breath ammonia | en_US |
dc.subject | blood urea nitrogen | en_US |
dc.subject | chronic kidney disease | en_US |
dc.subject | dialysis | en_US |
dc.title | Correlation between breath ammonia and blood urea nitrogen levels in chronic kidney disease and dialysis patients | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1088/1752-7163/ab728b | en_US |
dc.identifier.journal | JOURNAL OF BREATH RESEARCH | en_US |
dc.citation.volume | 14 | en_US |
dc.citation.issue | 3 | en_US |
dc.citation.spage | 0 | en_US |
dc.citation.epage | 0 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | 物理研究所 | zh_TW |
dc.contributor.department | 光電工程學系 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.contributor.department | Institute of Physics | en_US |
dc.contributor.department | Department of Photonics | en_US |
dc.identifier.wosnumber | WOS:000531232800001 | en_US |
dc.citation.woscount | 0 | en_US |
Appears in Collections: | Articles |